Most Read Articles
Audrey Abella, 15 May 2020
In adults with atrial fibrillation (AF) after percutaneous coronary intervention (PCI), dual therapy (direct oral anticoagulant [DOAC] + P2Y12 inhibitor) reduces the risk of bleeding compared with triple therapy (vitamin K antagonist [VKA] + DAPT* [aspirin and P2Y12 inhibitor]), a meta-analysis has shown. However, its effects on the risks of mortality and ischaemic endpoints** remain unclear.
09 May 2020
Use of aspirin during the implantation window of the menstrual cycle appears to increase fecundability, reveals a recent study.
Rachel Soon, 08 Apr 2020

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Roshini Claire Anthony, 2 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Antibiotics, corticosteroids reduce treatment failure in adults with COPD exacerbation

28 Feb 2020

Use of antibiotics and systemic corticosteroids can help decrease treatment failure in adults with mild-to-severe exacerbation of chronic obstructive pulmonary disease (COPD), results of a systematic review and meta-analysis have shown.

The investigators performed English-language searches of several bibliographic sources from database inception through 2 January 2019 and were able to identify 68 randomized controlled trials. Included studies enrolled adults with COPD exacerbation treated in out- or inpatient settings other than intensive care and compared pharmacologic therapies with placebo, usual care or other interventions. In addition, two independent reviewers extracted data and rated study quality and strength of evidence (SOE).

Treatment with antibiotics for 3–14 days, compared with placebo or management without antibiotics, led to increased resolution of COPD exacerbation (odds ratio [OR], 2.03, 95 percent confidence interval [CI], 1.47–2.80; moderate SOE) and less treatment failure at the end of intervention (OR, 0.54, 95 percent CI, 0.34–0.86; moderate SOE), independent of severity of exacerbation in out- and inpatients.

In addition, systemic corticosteroids given for 9–56 days, compared with placebo, in out- and inpatients also resulted in less treatment failure at the end of intervention (OR, 0.01, 95 percent CI, 0.00–0.13; low SOE) but was associated with a higher number of total and endocrine-related adverse events (AEs).

On the other hand, there were insufficient evidence for other pharmacologic intervention (eg, aminophyllines, magnesium sulfate, anti-inflammatory agents, inhaled corticosteroids and short-acting bronchodilators), compared with placebo or usual care, in inpatients, showing either no or inconclusive effects (except for mucolytic erdosteine) or improvement only in lung function.

The study was limited by scant evidence for many interventions, and several trials had unclear or high risk of bias and inadequate reporting of AEs, according to the investigators.

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Most Read Articles
Audrey Abella, 15 May 2020
In adults with atrial fibrillation (AF) after percutaneous coronary intervention (PCI), dual therapy (direct oral anticoagulant [DOAC] + P2Y12 inhibitor) reduces the risk of bleeding compared with triple therapy (vitamin K antagonist [VKA] + DAPT* [aspirin and P2Y12 inhibitor]), a meta-analysis has shown. However, its effects on the risks of mortality and ischaemic endpoints** remain unclear.
09 May 2020
Use of aspirin during the implantation window of the menstrual cycle appears to increase fecundability, reveals a recent study.
Rachel Soon, 08 Apr 2020

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Roshini Claire Anthony, 2 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates.