Most Read Articles
08 Nov 2018
Infants born through caesarean delivery appear to be at higher risk of food allergies, while those born very preterm have lower risks, a recent study has found.
04 Nov 2018
Home-based behavioural therapy, administered by parents with over-the-phone assistance with a therapist, effectively reduces complex motor stereotypies in children, a new study has found.
Jairia Dela Cruz, 15 Oct 2018
Infants treated with phototherapy are at increased risk of developing seizures in childhood, with the risk more pronounced in boys and independent of bilirubin levels, a study has found.
28 Oct 2018
Schoolchildren with severe eczema are at heightened risk of mental health problems including emotional symptoms, conduct problems, hyperactivity/inattention and peer problems, a study has found.

Antibiotic exposure does not elevate risk of BPD, death in preterm infants

18 Jun 2018
Interestingly, ACCESS found that antibiotic use in childhood appeared to keep IBD at bay.

Among preterm infants without culture-confirmed sepsis, exposure to antibiotics in the first week of life is not independently associated with an elevated risk of bronchopulmonary dysplasia (BPD) or death, according to a study.

A total of 4,950 infants were included, of whom 3,946 received antibiotics during the first week of life. Those treated with antibiotics had significantly higher rates of BPD of death (41.5 percent vs 31.1 percent; p<0.001) and the two individual outcomes.

However, after adjusting for potential confounding variables, no association was observed between antibiotic use in the first week of life and increased risk of BPD or death (odds ratio [OR], 0.96; 95 percent CI, 0.76–1.21), or BPD among survivors (OR, 0.86; 0.67–1.09).

Furthermore, antibiotic use correlated with increased risk of death prior to 36 weeks postmenstrual age (PMA; OR, 3.01; 1.59–5.71), but secondary analyses showed that unmeasured illness severity may confound this association.

An earlier study involving very low birth weight infants found that each additional day of antibiotic therapy during the first 2 weeks of life correlated with both an increased risk and severity of BPD. [J Pediatr 2017;181:289-293.e1]

Data from the Optum Neonatal Database were obtained for this retrospective cohort study. Participants included infants without culture-confirmed sepsis born <1,500 g and <32 weeks gestation between January 2010 and November 2016.

The authors used multivariable logistic regression to assess the independent association between antibiotic therapy during the first week of life and BPD or death prior to 36 weeks PMA.

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Most Read Articles
08 Nov 2018
Infants born through caesarean delivery appear to be at higher risk of food allergies, while those born very preterm have lower risks, a recent study has found.
04 Nov 2018
Home-based behavioural therapy, administered by parents with over-the-phone assistance with a therapist, effectively reduces complex motor stereotypies in children, a new study has found.
Jairia Dela Cruz, 15 Oct 2018
Infants treated with phototherapy are at increased risk of developing seizures in childhood, with the risk more pronounced in boys and independent of bilirubin levels, a study has found.
28 Oct 2018
Schoolchildren with severe eczema are at heightened risk of mental health problems including emotional symptoms, conduct problems, hyperactivity/inattention and peer problems, a study has found.