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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
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Antibacterial antibodies suppressed among MM patients

13 Dec 2020

Despite infection being a common complication of multiple myeloma (MM), antibacterial antibodies seem to be present in low levels, a recent study has found.

The findings “demonstrate the need to protect patients against infections at diagnosis, during anti-myeloma therapy, and importantly also during remission phases. Prophylactic antibiotics and patient education should be considered during active disease/when patients are undergoing therapy,” said the researchers.

The study included 836 MM patients (median age, 67 years; 63 percent male) enrolled in the TEAMM* trial. At diagnosis, serum levels of polyclonal immunoglobulin (Ig) G, A, and M were below the reference range in 71 percent, 83 percent, and 90 percent of the patients, respectively.

In 196 patients with paired follow-up data for IgG, median levels increased from 4.4 to 6.6 g/L over 1 year, with the proportion of patients with IgG within the reference range growing from 25 percent to 57 percent. A similar effect was reported for IgA and IgM.

Similarly, only 20 percent of the MM patients had protective IgG antibody levels against any of the 19 bacterial antigen targets assessed. Among healthy controls, 55 percent had such protection. As an illustration, only pneumococcal serotype 14 had adequate protection in MM patients, with 60 percent achieving acceptable serum thresholds.

Over a year of follow-up, the antibody levels against polysaccharide antigens further dropped, as did the proportion of patients protected. For haemophilus and meningococcal serotypes C, W, and Y, most patients saw antibody levels 50–100-times weaker than the protective threshold.

*Tracking early morbidity and mortality in myeloma

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.