Most Read Articles
Roshini Claire Anthony, 6 days ago

Patients with advanced, unresectable melanoma may derive overall survival (OS) and progression-free survival (PFS) benefits when treated with a nivolumab plus ipilimumab combination or nivolumab alone, according to 4-year results of the phase III CheckMate 067* trial presented at ESMO 2018.

28 Sep 2018
In Malaysia, hidradenitis suppurativa has a male preponderance, occurring at an early age with greater disease severity, as reported in a recent study.
15 Oct 2018
New drug applications approved by US FDA as of 1 - 15 October 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Audrey Abella, 22 Oct 2018
Consumption of any dairy (eg, milk, yogurt, and cheese) regardless of amount or frequency was associated with an increased risk for acne compared with no dairy intake in children, adolescents, and young adults, a meta-analysis has shown.

Anti-TNF agents may contribute to increased risk of psoriasiform diseases in IBD

04 Jul 2018

Use of antitumour necrosis factor (anti-TNF) agents in patients with inflammatory bowel disease (IBD) appears to be associated with an increased likelihood of developing psoriasiform diseases, with the risk of palmoplantar pustulosis most pronounced in males and younger patients, according to a study.

Drawing data from the Korea National Health Insurance Claim Data, researchers looked at 5,428 IBD patients treated with any anti‐TNF agent for >6 months (anti‐TNF group) and 10,856 matched controls who had never taken anti‐TNF agents (control group).

Psoriasis occurred with significantly greater frequency in the anti‐TNF vs control group (36.8 vs 14.5 per 10,000 person‐years). Use of anti-TNF was associated with a more than twofold increase in the risk of developing psoriasis (hazard ratio [HR], 2.357; 95 percent CI, 1.668–3.331).

Moreover, the anti-TNF group had greater risks of palmoplantar pustulosis (HR, 9.355; 2.754–31.780) and psoriatic arthritis (HR, 2.926; 1.640–5.218).

When analyses were stratified according to IBD subtypes, anti-TNF agent use was associated with a heightened risk of psoriasis in both Crohn’s disease (HR, 2.549; 1.658–3.920) and ulcerative colitis (HR, 2.105; 1.155–3.836).

Of note, the risk of palmoplantar pustulosis was markedly higher in subgroups of male (HR, 19.682; 3.867–100.169) and younger (aged 10–39 years; HR, 14.318; 2.915–70.315) patients exposed to anti-TNF agents.

The present data underscore the need for evaluating paradoxical psoriasiform diseases carefully when prescribing or considering anti‐TNF agents for IBD patients, as researchers pointed out. More studies are warranted to characterize the predictive factors for this phenomenon.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Patients with advanced, unresectable melanoma may derive overall survival (OS) and progression-free survival (PFS) benefits when treated with a nivolumab plus ipilimumab combination or nivolumab alone, according to 4-year results of the phase III CheckMate 067* trial presented at ESMO 2018.

28 Sep 2018
In Malaysia, hidradenitis suppurativa has a male preponderance, occurring at an early age with greater disease severity, as reported in a recent study.
15 Oct 2018
New drug applications approved by US FDA as of 1 - 15 October 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Audrey Abella, 22 Oct 2018
Consumption of any dairy (eg, milk, yogurt, and cheese) regardless of amount or frequency was associated with an increased risk for acne compared with no dairy intake in children, adolescents, and young adults, a meta-analysis has shown.