Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Anlotinib a new treatment alternative for thyroid cancer?

Audrey Abella
30 Nov 2020

Anlotinib demonstrated high survival benefit and treatment response rates in patients with locally advanced and metastatic radio-iodine-refractory differentiated thyroid carcinoma (RAIR-DTC), a phase II study from China has shown.

In 2014, about 170,000 new cases of TC were diagnosed in China, most of which were DTC. [Chin J Cancer Res 2018;30:1-12] About 10 percent of DTC will become RAIR within 10 years, with a 3-year overall survival (OS) rate of <50 percent; hence, patients with RAIR-DTC have poor outcomes. [Clin Transl Oncol 2011;13:574-579; Cancers (Basel) 2019;11(9):1382]

A novel tyrosine kinase inhibitor targeting VEGFR, FGFR, PDGFR*, and c-Kit, anlotinib has gained approval from the China NMPA** in 2018 as third-line treatment for advanced non-small-cell lung cancer (NSCLC). [Cancer Commun 2019;39:36]

The investigators sought to determine whether the benefit of anlotinib in NSCLC may extend to RAIR-DTC. They randomized 113 patients (median age 56 years, 67 percent female) 2:1 to receive 3-week cycles (2 weeks on, 1 week off) of anlotinib 12 mg QD or placebo. Median durations of treatment were 34 and 12 cycles for anlotinib and placebo, respectively. Sixty-five percent of placebo recipients crossed over to open-label anlotinib following disease progression. [ESMO Asia 2020, abstract 265O]

Progression-free survival (PFS) was significantly longer with anlotinib vs placebo, thus meeting the primary endpoint (median, 40.5 vs 8.4 months; hazard ratio [HR], 0.21; p<0.0001). Median PFS remained significant even after stratifying patients progressing within 3 months (median, not evaluable [NE] vs 6.9 months; HR, 0.13) and 12 months (median, NE vs 8.4 months; HR, 0.18; p<0.0001 for both).

The higher percentage of women vs men on anlotinib (57 percent vs 43 percent) may partly explain for the longer median PFS, as women have a relatively lower risk of TC progression, noted Dr Yihebali Chi from the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, who presented the findings.

Anlotinib use was also associated with higher objective response rate (59 percent vs 0 percent; p<0.0001) and disease control rate (97 percent vs 78 percent; p=0.002) compared with placebo use.

Anlotinib had a favourable safety and tolerability profile, with a relatively low incidence of serious treatment-related adverse events (AEs; 16 percent) and dose reductions (34 percent). The most common AEs observed with anlotinib use were hypertension (84 percent) and hand-foot syndrome (74 percent).

EORTC QLQ-C30*** scores (15# items) were generally similar between groups, both at baseline and after 12 cycles, noted Chi. “[This suggests that] anlotinib had no obvious impact on quality of life … [potentially due to the] decreased tumour burden and TRAEs … [T]he steady scores in the placebo arm [may be due to the fact] that only patients without disease progression received the questionnaires at each assessment,” she explained.

Mortality rate was lower with anlotinib vs placebo (26 percent vs 38 percent; HR, 0.57; p=0.098). Moreover, a significant OS benefit was observed after adjusting for potential bias from the crossover from placebo to anlotinib (HR, 0.36; p=0.0033). However, OS data are still immature, stressed Chi.

“[Nonetheless,] the study demonstrates the efficacy and safety of anlotinib and supports its use as a new option for the treatment of locally advanced or metastatic RAIR-DTC,” she concluded.

 

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.