Most Read Articles
Roshini Claire Anthony, 11 Feb 2020

The consumption of processed meat or unprocessed red meat may be associated with a slightly elevated risk of incident cardiovascular disease (CVD)* and all-cause mortality, according to a US study.

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Use of the PCSK9* inhibitor alirocumab in acute coronary syndrome (ACS) patients on a background of high-intensity statin treatment delivers reductions in total hospitalizations and death with corresponding gains in days alive and out of hospital (DAOH), according to the results of prespecified and posthoc analyses of the ODYSSEY OUTCOMES** trial presented at the American Heart Association (AHA) 2019 Scientific Sessions.
Roshini Claire Anthony, 06 Feb 2020

The presence of metabolic syndrome* appears to increase the risk of recurrent venous thromboembolism (VTE)** among patients with deep vein thrombosis (DVT), a recent study showed.

Jairia Dela Cruz, 13 Feb 2020
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Angiogenic factors hold promise in triage of women with suspected pre-eclampsia

04 Sep 2019

Measuring the ratio of the soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) improves the accuracy of identifying pre-eclampsia without changing admission rates, according to the results of a trial.

The trial assessed the utility of sFlt-1/PlGF ratio in 370 women presenting with suspected pre-eclampsia who were then randomly allocated to groups that did (n=186) and did not (n=184) reveal the result of the test to clinicians.  

Researchers used a ratio cutoff of 38 to define low (≤38) and elevated risk (>38) of developing pre-eclampsia in the subsequent week. The primary outcome was hospitalization within 24 hours of the test, while secondary outcomes included development of pre-eclampsia and other adverse maternal–foetal outcomes.

Pre-eclampsia occurred in 85 women (23 percent) overall. The number of admissions did not significantly differ between the reveal and nonreveal groups (48 vs 60; p=0.192). All women who developed the pregnancy disorder in the reveal group were admitted within 7 days, as compared with 83 percent of those in the nonreveal group (p=0.038).

For predicting the development of pre-eclampsia within 7 days, the sFlt-1/PlGF ratio test yielded a sensitivity of 100 percent (95 percent CI, 85.8–100) and a negative predictive value (NPV) of 100 percent (97.1–100). In comparison, clinical practice alone achieved 83.3 percent (58.6–96.4) sensitivity and 97.8 percent (93.7–99.5) NPV.

The researchers also noted a trend towards reduced time to diagnosis of the pregnancy disorder when using the test. Taken together, the findings suggest that he sFlt-1/PlGF ratio test allows the correct triage and hospitalization of women with suspected pre-eclampsia without changing admission rates.

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Most Read Articles
Roshini Claire Anthony, 11 Feb 2020

The consumption of processed meat or unprocessed red meat may be associated with a slightly elevated risk of incident cardiovascular disease (CVD)* and all-cause mortality, according to a US study.

Jairia Dela Cruz, 25 Nov 2019
Use of the PCSK9* inhibitor alirocumab in acute coronary syndrome (ACS) patients on a background of high-intensity statin treatment delivers reductions in total hospitalizations and death with corresponding gains in days alive and out of hospital (DAOH), according to the results of prespecified and posthoc analyses of the ODYSSEY OUTCOMES** trial presented at the American Heart Association (AHA) 2019 Scientific Sessions.
Roshini Claire Anthony, 06 Feb 2020

The presence of metabolic syndrome* appears to increase the risk of recurrent venous thromboembolism (VTE)** among patients with deep vein thrombosis (DVT), a recent study showed.

Jairia Dela Cruz, 13 Feb 2020
For regular drinkers with atrial fibrillation (AF), cutting down alcohol consumption confers beneficial effects on both the AF burden and risk of recurrence, according to a recent study.