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3 days ago
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Angiogenic factors hold promise in triage of women with suspected pre-eclampsia

04 Sep 2019

Measuring the ratio of the soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) improves the accuracy of identifying pre-eclampsia without changing admission rates, according to the results of a trial.

The trial assessed the utility of sFlt-1/PlGF ratio in 370 women presenting with suspected pre-eclampsia who were then randomly allocated to groups that did (n=186) and did not (n=184) reveal the result of the test to clinicians.  

Researchers used a ratio cutoff of 38 to define low (≤38) and elevated risk (>38) of developing pre-eclampsia in the subsequent week. The primary outcome was hospitalization within 24 hours of the test, while secondary outcomes included development of pre-eclampsia and other adverse maternal–foetal outcomes.

Pre-eclampsia occurred in 85 women (23 percent) overall. The number of admissions did not significantly differ between the reveal and nonreveal groups (48 vs 60; p=0.192). All women who developed the pregnancy disorder in the reveal group were admitted within 7 days, as compared with 83 percent of those in the nonreveal group (p=0.038).

For predicting the development of pre-eclampsia within 7 days, the sFlt-1/PlGF ratio test yielded a sensitivity of 100 percent (95 percent CI, 85.8–100) and a negative predictive value (NPV) of 100 percent (97.1–100). In comparison, clinical practice alone achieved 83.3 percent (58.6–96.4) sensitivity and 97.8 percent (93.7–99.5) NPV.

The researchers also noted a trend towards reduced time to diagnosis of the pregnancy disorder when using the test. Taken together, the findings suggest that he sFlt-1/PlGF ratio test allows the correct triage and hospitalization of women with suspected pre-eclampsia without changing admission rates.

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Most Read Articles
3 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 2 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.