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Anaerobes, S. anginosus among most common bacteria in children with complicated appendicitis

14 Nov 2019
Five-year-old Karis Cochrane suffered from a ruptured appendix which doctors failed to identify in her earlier visits. Photo credit: Daily Record/Mirrorpix

Streptococcus anginosus, aminoglycoside-susceptible Gram-negative bacilli and anaerobes remain the most common bacteria in previously healthy children presenting with complicated appendicitis requiring surgical drainage, reports a study.

A total of 425 children with primary acute appendicitis were included, among whom 158 (37 percent) had complicated appendicitis at presentation. Of the 133 patients who underwent a surgical or interventional radiologic intervention, 53 (40 percent) had bacterial culture.

Those with peritoneal cultures had a higher likelihood of having longer symptom duration prior to admission (3 [interquartile rage, 2–5] vs 2 [interquartile range, 1–2] days; p<0.001) and purulent peritonitis (47 percent [23/53] vs 13 percent [10/80]; p<0.001).

The most common pathogens isolated were anaerobes (81 percent), Escherichia coli (74 percent) and S. anginosus group (62 percent). Of the isolated bacteria, only 4 percent showed resistance to empiric therapy.

Twenty-three (17 percent) patients had postoperative infectious complications. Such complications were associated with more severe disease and higher C-reactive protein values (303 vs 83 mg/L; p=0.03) at presentation but not with the presence of a resistant pathogen or the choice of antimicrobial agents.

“In an attempt to reduce extended-spectrum cephalosporin use, these data were useful in supporting the use of metronidazole with ampicillin and an aminoglycoside, rather than third-generation cephalosporins,” the investigators said.

This retrospective cohort study was conducted from 1 February 2017 to 31 October 2018 in children who underwent appendectomy or interventional radiologic drainage for primary complicated appendicitis.

The proportion of patients who had a pathogen isolated from peritoneal fluid culture that was not susceptible to the recommended empiric therapy was the primary outcome. Total duration of antimicrobial therapy and the proportion of patients with a postoperative infectious complication within 30 days after intervention were the secondary outcomes.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
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Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
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Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.