Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Anaemia risk factor for death in heart failure

19 Jan 2020

Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.

Researchers enrolled 49,985 patients with HF. Anaemia was defined as having haemoglobin <120 g/L in women, and <130 g/L in men. Outcomes included the time to all-cause mortality or first HF hospitalization. Thirty-four percent of the population were found to have anaemia.

Majority (55 percent) of the patients had HFrEF, while 23 percent and 21 percent had HFpEF and HFmrEF, respectively. The prevalence rates of anaemia in the respective EF subgroups were 32 percent, 41 percent and 35 percent.

Logistic regression analysis, adjusted for baseline confounders, showed that anaemia was significantly more likely to occur in both HFpEF (odds ratio [OR], 1.55, 95 percent confidence interval [CI], 1.46–1.65) and HFmrEF (OR, 1.24, 95 percent CI, 1.17–1.31) patients than in their HFrEF counterparts.

In turn, anaemia led to worse outcomes in all EF groups. Multivariable Cox regression models found that survival free of hospitalization was significantly lower in HFpEF (adjusted hazard ratio [HR], 1.24, 95 percent CI, 1.18–1.30), HFmrEF (adjusted HR, 1.26, 95 percent CI, 1.19–1.34) and HFrEF (adjusted HR, 1.14, 1.10–1.19) patients with anaemia than their nonanaemic comparators.

The risk of mortality was likewise elevated in anaemic HFpEF (adjusted HR, 1.28, 95 percent CI, 1.20–1.36), HFmrEF (adjusted HR, 1.21, 1.13–1.29) and HFrEF (adjusted HR, 1.30, 1.24–1.35) patients.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.