Most Read Articles
Audrey Abella, 6 days ago
Individuals with left main coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) continued to show similar rates of the primary outcome (composite of death, stroke, or myocardial infarction), highlighting the potential of PCI as a CABG alternative in this patient setting, according to the final r­esults of the EXCEL* trial presented at TCT 2019.

Anaemia predicts cardiovascular, renal events in hypertensives

12 Jun 2019

Anaemia predicts cardiovascular and renal events in hypertensive patients with well-controlled blood pressure, reports a recent study.

Accessing the ATTEMPT-CVD* study, researchers divided 1,213 participants into those who were (n=194; mean age, 70.5±8.5 years; 43 percent male) or were not (n=1,019; mean age, 65.5±9.3 years; 61 percent male) anaemic based on their baseline haemoglobin concentrations. The incidence rates of renal and cardiovascular events were compared between groups, as was blood pressure.

The mean haemoglobin in the anaemic and nonanaemic groups were 11.5±0.8 and 14.4±1.3 g/dL, respectively. Cox proportional hazards analysis showed that the incidence of cardiovascular and renal events was significantly elevated in participants positive for anaemia (hazard ratio [HR], 1.945, 95 percent CI, 1.208–3.130; p=0.0062).

This was specifically true in males (HR, 2.246, 1.213–4.159; p=0.0101), while in females, statistical significance was not achieved (p=0.0749). There was no significant correlation between anaemia and sex (p=0.7875).

Multivariable analysis combined with backward selection further confirmed the significant and independent value of being diagnosed with anaemia for predicting cardiovascular and renal events (adjusted HR, 1.816, 1.116–2.955; p=0.0163).

Other predictors included the male sex (adjusted HR, 1.681, 1.070–2.642; p=0.0242), prior diabetes (adjusted HR, 2.945, 1.688–5.138; p=0.0001) and cardiovascular disease (adjusted HR, 2.445; 1.492–4.007; p=0.0004), and plasma brain natriuretic peptide level ≥19 ng/mL (adjusted HR, 2.049, 1.296–3.240; p=0.0021).

* A trial of telmisartan prevention of cardiovascular disease

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Audrey Abella, 6 days ago
Individuals with left main coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) continued to show similar rates of the primary outcome (composite of death, stroke, or myocardial infarction), highlighting the potential of PCI as a CABG alternative in this patient setting, according to the final r­esults of the EXCEL* trial presented at TCT 2019.