Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Pearl Toh, 6 days ago
Daily intake of sugar-sweetened beverages was associated with elevated triglyceride levels and lower HDL cholesterol levels, both of which are risk factors for cardiovascular disease (CVD), according to the Framingham Heart Study with up to 23 years of follow-up.
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.

Anaemia linked to progression of nonproliferative to vision-threatening diabetic retinopathy

18 May 2020

Anaemia appears to be involved in the progression from nonproliferative diabetic retinopathy (NPDR) to vision-threatening diabetic retinopathy (VTDR), a recent study has found.

Researchers performed a retrospective cohort study on 69,982 NPDR patients. Anaemia and other oxygen delivery-related comorbidities, such as chronic pulmonary disease, were identified from patient records. The primary study outcome was a new diagnosis of VTDR, proliferative diabetic retinopathy (PDR) or diabetic macular oedema (DME).

Most of the participants (n=57,212; mean age, 61.7±12.9 years; 53.5 percent male) did not progress to VTDR, while the remaining 12,770 (mean age, 60.5±12.1 years; 50.9 percent male) did.

Cox proportional hazards analysis found that after controlling for covariates, mild (hazard ratio [HR], 1.10, 95 percent confidence interval [CI], 1.04–1.16; p<0.001) and moderate/severe (HR, 1.20, 95 percent CI, 1.12–1.29; p<0.001) forms of anaemia were significantly associated with the progression to VTDR.

The same was true for the individual components of VTDR. Mild (HR, 1.29, 95 percent CI, 1.13–1.46; p<0.001) and moderate/severe (HR, 1.43, 95 percent CI, 1.21–1.69; p<0.001) anaemia increased the risk of PDR, as well as of DME (mild: HR, 1.06, 95 percent CI, 1.00–1.13; p<0.001; moderate/severe: HR, 1.14, 95 percent CI, 1.05–1.24; p<0.001).

Other oxygen delivery-related comorbidities also increased the risk of VTDR. This was observed with chronic pulmonary disease (HR, 1.10, 95 percent CI, 1.06–1.14; p<0.001) and a history of blood disorders or cancer (HR, 1.28, 95 percent CI, 1.16–1.40; p<0.001). This effect was driven largely by the effect of the comorbidities on DME risk.

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Pearl Toh, 6 days ago
Daily intake of sugar-sweetened beverages was associated with elevated triglyceride levels and lower HDL cholesterol levels, both of which are risk factors for cardiovascular disease (CVD), according to the Framingham Heart Study with up to 23 years of follow-up.
Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.