Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
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Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

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Ambulatory blood pressure helps predict progression of cerebral small vessel disease

24 Jun 2020
The new AHA guidelines has lowered the blood pressure limit to 130/80mmHg from 140/90mmHg. Does it really matter?

Ambulatory blood pressure monitoring (ABPM) may be useful in assessing the risk of cerebral small vessel disease (cSVD) progression in elderly adults, a recent study has found.

A total of 233 participants (median age, 65 years; 43.8 percent female) were enrolled, in whom ambulatory systolic (SBP) and diastolic (DBP) blood pressure were measured. Cutoff points for determining good or poor control were 125/75 mm Hg over a 24-hour period, 130/80 mm Hg during the day, and 110/65 mm Hg at night. Progression of cSVD was qualitatively scored.

Around a quarter (26.2 percent; n=61) of the participants showed minor cSVD progression, characterized by just one magnetic resonance imaging (MRI) lesion. In comparison, 9.9 percent (n=23) showed marked progression, defined as having at least two MRI markers.

High ambulatory SBP and DBP at any time point correlated with an increased risk of new cSVD lesions, an interaction that remained true even after controlling for confounders. Night-time pulse pressure (PP) likewise emerged as a predictor of incident lesions.

Poor 24-hour DBP control at baseline (odds ratio [OR], 2.55, 95 percent confidence interval [CI], 1.36–4.78; p=0.004) as well as night-time PP (OR per 1-mm Hg increase, 1.03, 95 percent CI, 1.00-1.06; p=0.023) were significant predictors of cSVD progression.

“These results indicate that ambulatory BP, or equivalent measurements, should be obtained more routinely,” researchers said. “Future studies should combine ABPM information with other clinical variables to refine the risk prediction of cSVD progression.”

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Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
Maternal stress during pregnancy correlates with rapid weight gain of her infant, a recent study has found.