Most Read Articles
Elvira Manzano, Yesterday
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, Yesterday
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.

Ambulatory blood pressure helps predict progression of cerebral small vessel disease

24 Jun 2020
The new AHA guidelines has lowered the blood pressure limit to 130/80mmHg from 140/90mmHg. Does it really matter?

Ambulatory blood pressure monitoring (ABPM) may be useful in assessing the risk of cerebral small vessel disease (cSVD) progression in elderly adults, a recent study has found.

A total of 233 participants (median age, 65 years; 43.8 percent female) were enrolled, in whom ambulatory systolic (SBP) and diastolic (DBP) blood pressure were measured. Cutoff points for determining good or poor control were 125/75 mm Hg over a 24-hour period, 130/80 mm Hg during the day, and 110/65 mm Hg at night. Progression of cSVD was qualitatively scored.

Around a quarter (26.2 percent; n=61) of the participants showed minor cSVD progression, characterized by just one magnetic resonance imaging (MRI) lesion. In comparison, 9.9 percent (n=23) showed marked progression, defined as having at least two MRI markers.

High ambulatory SBP and DBP at any time point correlated with an increased risk of new cSVD lesions, an interaction that remained true even after controlling for confounders. Night-time pulse pressure (PP) likewise emerged as a predictor of incident lesions.

Poor 24-hour DBP control at baseline (odds ratio [OR], 2.55, 95 percent confidence interval [CI], 1.36–4.78; p=0.004) as well as night-time PP (OR per 1-mm Hg increase, 1.03, 95 percent CI, 1.00-1.06; p=0.023) were significant predictors of cSVD progression.

“These results indicate that ambulatory BP, or equivalent measurements, should be obtained more routinely,” researchers said. “Future studies should combine ABPM information with other clinical variables to refine the risk prediction of cSVD progression.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elvira Manzano, Yesterday
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, Yesterday
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.