Most Read Articles
15 Sep 2018
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
13 Sep 2018
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
Tristan Manalac, 2 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.

Altered brain structure a potential indicator of venous erectile dysfunction

02 Jul 2018

Patients with venous erectile dysfunction (VED) exhibit cortical volume and white matter (WM) microstructural changes on multimodal magnetic resonance imaging (MRI), and such cerebral structural alterations are correlated with clinical symptoms and neurologic impairments, as shown in a recent study.

The study included 45 VED patients (mean age 29.8 years) and 50 healthy controls (mean age 28.1 years) who underwent MRI. The resulting imaging data were analysed using voxel-based morphometry (VBM), tract-based spatial statistics (TBSS) and Pearson correlation analyses. The machine learning classification was adopted to confirm its utility in distinguishing between VED patients and healthy controls.

Compared with healthy controls, VED patients had significantly reduced cortical volumes in the left postcentral gyrus and precentral gyrus, whereas only the right middle temporal gyrus showed a significantly greater cortical volume.

VED patients also showed increased axial diffusivity, radial diffusivity and mean diffusivity values in widespread brain regions. In certain regions, these diffusion tensor imaging (DTI)-derived indices significantly correlated with clinical symptoms and disorder durations in VED.

Machine learning analyses corroborated the differences in the various DTI-derived indices between VED patients and healthy controls. Additionally, the differences discriminated patients from controls with high accuracy (96.7 percent), sensitivity (93.3 percent) and specificity (99.0 percent).

The present data suggest the utility of MRI in the assessment of patients with VED, researchers said. Furthermore, the various DTI-derived indices of some brain regions could be regarded as reliable discrimination features between VED patients and healthy individuals.

However, the potential use of DTI necessitates validation in longitudinal studies and comparison with patient groups showing similar clinical presentations, they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
15 Sep 2018
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
13 Sep 2018
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
Tristan Manalac, 2 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.