Most Read Articles
Pearl Toh, 6 days ago
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
3 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Rachel Soon, 02 Aug 2018

Older men who report erectile dysfunction (ED) may be at greater risk of cardiovascular disease (CVD) independent of other risk factors such as LDL cholesterol, smoking and high blood pressure.

21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Alpha fetoprotein improves ultrasound sensitivity for early HCC detection

13 May 2018

Addition of alpha fetoprotein (AFP) to ultrasound significantly improves the detection of early stage hepatocellular carcinoma (HCC) in patients with cirrhosis, a recent meta-analysis has found.

Pooled results from 15 studies (n=4,400) showed that the sensitivity of ultrasound alone for detection of early stage HCC was 47 percent (95 percent CI, 33–61 percent). Sensitivity for detection at any stage, as assessed in 31 studies (n=12,977), was higher at 84 percent (76–92 percent).

Similarly, accuracy of ultrasound alone for HCC detection at early stages was low (area under the curve [AUC], 0.88; 0.85–0.90). Accuracy was higher for detection at any stage (AUC, 0.96; 0.94–0.98).

The findings were robust even after the inclusion of patients without cirrhosis, which did not cause significant changes in the sensitivity of ultrasound alone for early HCC detection (p=0.89).

Eighteen studies (n=8,526) directly compared ultrasound with and without AFP for the detection of HCC at any stage. The pooled sensitivity of ultrasound was significantly lower when used alone vs when used with AFP (78 percent vs 97 percent; relative risk [RR], 0.88; 0.83–0.93).

A similar trend was observed for detection of early-stage HCC using ultrasound alone vs in combination with AFP (45 percent vs 63 percent; RR, 0.81; 0.71–0.93). The beneficial effect of AFP was consistent across different subgroup analyses.

For the meta-analysis, the databases of Medline and Scopus were accessed for studies that monitored for HCC development using abdominal imaging with or without AFP. A total of 32 studies were eligible for inclusion, all of which were observational in nature.

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Most Read Articles
Pearl Toh, 6 days ago
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
3 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Rachel Soon, 02 Aug 2018

Older men who report erectile dysfunction (ED) may be at greater risk of cardiovascular disease (CVD) independent of other risk factors such as LDL cholesterol, smoking and high blood pressure.

21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.