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29 Nov 2019
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Alopecia areata tied to various comorbidities

15 Jan 2019

Alopecia areata (AA) is associated with a variety of comorbid conditions such as metabolic syndrome, iron deficiency anaemia and Helicobacter pylori infections, a recent meta-analysis has shown.

Applying the selection criteria yielded a total of 87 studies, four of which were cohort studies that focused on incident disease. Majority (n=83) investigated prevalent disease of either case-control (n=41) or cross-sectional (n=42) designs.

Atopic diseases were common AA comorbidities, with patients showing significantly elevated odds of having atopic dermatitis (odds ratio [OR], 2.36; 95 percent, 1.80–3.09) and allergic rhinitis (OR, 1.33; 1.19–1.47). Asthma showed prevalence that trended toward significance (OR, 1.11; 0.88–1.46).

Cardiovascular diseases also frequently occurred with AA. Hyperinsulinaemia (OR, 3.52; 1.43–8.71) and metabolic syndrome (OR, 3.68; 1.22–11.08) appeared to be more prevalent in AA patients, though data for these conditions came from only one small study. On the other hand, diabetes mellitus was significantly less likely to develop in AA patients (OR, 0.64; 0.57–0.73).

Other diseases significantly more prevalent in AA patients were H. pylori infections (OR, 2.03; 1.23–3.34), lupus erythematosus (OR, 4.73; 3.70–6.10) and incident autoimmune diseases (hazard ratio [HR], 1.86; 1.32–2.63) such as rheumatoid arthritis (HR, 1.79; 1.07–3.00), systemic lupus erythematosus (HR, 5.01; 2.08–12.05) and psoriasis (HR, 2.02; 1.06–3.83).

Anaemia (OR, 2.53; 1.45–4.40), particularly iron deficiency anaemia (OR, 2.78; 1.23–6.29), was also more common in AA patients, as was thyroid cancer (OR, 1.89; 1.53–2.34). Other solid organ malignancies showed weak correlations with AA.

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
4 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Pearl Toh, 4 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
3 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.