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Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Yesterday
Cryptococcosis is more common in nonhuman immunodeficiency virus (HIV) nontransplant (NHNT) patients, and this population tends to have more localized pulmonary cryptococcosis and significantly higher 90-day mortality, reports a study.
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Alopecia areata tied to various comorbidities

15 Jan 2019

Alopecia areata (AA) is associated with a variety of comorbid conditions such as metabolic syndrome, iron deficiency anaemia and Helicobacter pylori infections, a recent meta-analysis has shown.

Applying the selection criteria yielded a total of 87 studies, four of which were cohort studies that focused on incident disease. Majority (n=83) investigated prevalent disease of either case-control (n=41) or cross-sectional (n=42) designs.

Atopic diseases were common AA comorbidities, with patients showing significantly elevated odds of having atopic dermatitis (odds ratio [OR], 2.36; 95 percent, 1.80–3.09) and allergic rhinitis (OR, 1.33; 1.19–1.47). Asthma showed prevalence that trended toward significance (OR, 1.11; 0.88–1.46).

Cardiovascular diseases also frequently occurred with AA. Hyperinsulinaemia (OR, 3.52; 1.43–8.71) and metabolic syndrome (OR, 3.68; 1.22–11.08) appeared to be more prevalent in AA patients, though data for these conditions came from only one small study. On the other hand, diabetes mellitus was significantly less likely to develop in AA patients (OR, 0.64; 0.57–0.73).

Other diseases significantly more prevalent in AA patients were H. pylori infections (OR, 2.03; 1.23–3.34), lupus erythematosus (OR, 4.73; 3.70–6.10) and incident autoimmune diseases (hazard ratio [HR], 1.86; 1.32–2.63) such as rheumatoid arthritis (HR, 1.79; 1.07–3.00), systemic lupus erythematosus (HR, 5.01; 2.08–12.05) and psoriasis (HR, 2.02; 1.06–3.83).

Anaemia (OR, 2.53; 1.45–4.40), particularly iron deficiency anaemia (OR, 2.78; 1.23–6.29), was also more common in AA patients, as was thyroid cancer (OR, 1.89; 1.53–2.34). Other solid organ malignancies showed weak correlations with AA.

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Most Read Articles
Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Yesterday
Cryptococcosis is more common in nonhuman immunodeficiency virus (HIV) nontransplant (NHNT) patients, and this population tends to have more localized pulmonary cryptococcosis and significantly higher 90-day mortality, reports a study.
5 days ago
Type 2 diabetes (T2D) is an independent risk factor for all-cause dementia, with the greatest risk observed in patients who are insulin-dependent and obese, a recent study has found.