Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Allergen exposure aggravates cough response to capsaicin

12 Sep 2019

Exposure to allergens induces bronchoconstriction and increases the sensitivity of the cough reflex to capsaicin, a recent study has shown.

Researchers conducted a randomized, placebo-controlled, two-way crossover study including 12 steroid-naïve allergic asthma patients (mean age, 34.8 years; 50 percent female), whose response to inhaled capsaicin after allergen vs diluent control exposure was comparatively assessed. Spontaneous coughing was measured for 24 hours after allergen/diluent challenge.

The increase in the number of evoked coughs that induced the half-maximal response after capsaicin inhalation (ED50) was significantly greater after allergen vs diluent challenge (geometric mean coughs: 21.9 vs 12.1; p<0.001). Though the overall ED50 dropped after 24 hours, the difference between the allergen and diluent arms remained significant (16.1 vs 9.8; p=0.001).

Researchers also reported a significantly greater drop in lung function after allergen challenge in both the early (mean percent decrease: 38.2±13.0 percent vs 4.5±2.8 percent; p<0.001) and late (23.7±13.2 percent vs 2.2±2.1 percent; p<0.001) asthma response. This trend similarly persisted for 24 hours. Lung function was measured as the forced expiratory volume in 1 second.

There was also a significant increase in the rate of spontaneous coughs over 24 hours after allergen vs diluent challenge (geometric mean rate: 0.60 vs 0.25; p<0.001). This effect was statistically correlated with the drop in lung function (β, –0.72; p<0.001).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.