Most Read Articles
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

6 days ago
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
06 Aug 2019
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
15 Feb 2018
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.

Alendronate plus alfacalcidol yields BMD increases in myasthenia gravis patients

08 Jan 2018

Combination therapy with alendronate plus alfacalcidol appears to produce significant increases in bone mineral density (BMD) and reductions in bone turnover biomarker levels, and to lower the rate of hypercalciuria in myasthenia gravis (MG) patients who initiated treatment with glucocorticoids, according to a study.

The open-label study included 75 MG patients who were treated with 0.25 μg of alfacalcidol every other day and 600 mg of calcium daily. Patients with baseline BMD T-score of less than –1.0 received add-on 70 mg of alendronate per week (alendronate group), whereas those with T-score of greater than –1.0 did not (alfacalcidol-alone group).

Results revealed significant improvements in the alendronate group after 12 months of treatment. Specifically, mean BMD increased by 3.4 percent at lumbar spine (p=0.002), by 1.8 percent at femoral neck (p=0.21), and by 2.6 percent in the total hip region (p=0.02).

However, alfacalcidol monotherapy failed to prevent bone loss in MG patients. The mean BMD in the alfacalcidol-alone group decreased by 6.1 percent at lumbar spine, by 3.2 percent at femoral neck, and by 3.3 percent in the total hip region (p<0.001 for all).

In terms of safety, researchers noted a high incidence of hypercalciuria (≥7.5 mmol/24 hour) even after adjusting the dose of alfacalcidol or calcium supplements (40.9 percent in the alendronate group vs 50.9 percent in the alfacalcidol-alone group; p=0.46). At 12 months of treatment, hypercalciuria events were reported in only 10.5 percent in the alendronate group compared with 44.2 percent in the alfacalcidol-alone group.

There were no reports of osteonecrosis of the jaw, atypical fracture, and renal function impairment.
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Most Read Articles
Roshini Claire Anthony, 08 Apr 2019

About one-third of individuals who achieved remission of type 2 diabetes (T2D) after losing weight with an intensive weight management programme sustained their remission at 2 years, according to long-term results of the DiRECT* trial.

6 days ago
Progressive lipolysis may be reduced via the improved antilipolytic effect in adipose tissue, which leads to a reduction in future weight loss caused by sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes (T2D), suggests a recent study.
06 Aug 2019
Maternal prepregnancy obesity is associated with earlier age at voice break, pubic hair development, axillary hair and acne in sons, as well as with earlier age at menarche, breast development, pubic hair development, axillary hair and acne in daughters, a study has found. These associations appear to be mediated by higher childhood body mass index in sons and partly so in daughters.
15 Feb 2018
Long-term treatment with dual-release hydrocortisone (DR-HC) appears to produce favourable effects on insulin secretion and sensitivity in patients with prediabetes, according to a study. The treatment also confers benefits for metabolic and anthropometric parameters.