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Alcohol abuse cuts long-term survival from severe acute pancreatitis

05 Aug 2019

While short-term survival is good in young patients with severe acute pancreatitis (SAP), long-term survival is impaired by alcohol abuse, a recent study has shown.

Researchers conducted a retrospective analysis of 435 adults with SAP (median age, 48 years; 81.8 percent male) who underwent intensive care. Majority of the participants (77.0 percent; n=335) suffered from alcoholic SAP, though this was significantly more common among males (82.8 percent vs 48.8 percent; p<0.001).

A total of 357 participants survived to the 90-day follow-up, yielding a short-term survival rate of 82.1 percent. Those who were younger were more likely to survive (median, 47 years vs 61 years; p<0.001). Pancreatitis was the most common underlying cause of death (98.7 percent; n=77).

Stratifying participants according to age groups further highlighted the survival benefit of younger age. The survival rate was 89.5 percent in those <60 years of age and dropped progressively to 60.3 percent and 43.3 percent in patients 60–69 years and 70 years, respectively.

For long-term outcomes, participants were followed for a median of 5.8 years. The resulting 10-year survival estimates were 28.3 percent and 67.9 percent for those older and younger than 60 years, respectively.

Alcohol-related reasons accounted for more than half of the long-term deaths (57.1 percent; n=48). These included any underlying or immediate alcohol-related diseases, alcohol intoxication, and traumatic deaths associated with alcohol use. Acute pancreatitis was the cause of death in 22 (26.2 percent) late mortalities.

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Most Read Articles
4 days ago
Administering intranasal desmopressin to patients with renal dysfunction not requiring haemodialysis reduces bleeding complications during renal biopsies, especially minor complications such as perinephric haematomas, a study has found. However, it may increase the risk of incident hyponatraemia.
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Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
6 days ago
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