Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Alcohol abuse cuts long-term survival from severe acute pancreatitis

05 Aug 2019

While short-term survival is good in young patients with severe acute pancreatitis (SAP), long-term survival is impaired by alcohol abuse, a recent study has shown.

Researchers conducted a retrospective analysis of 435 adults with SAP (median age, 48 years; 81.8 percent male) who underwent intensive care. Majority of the participants (77.0 percent; n=335) suffered from alcoholic SAP, though this was significantly more common among males (82.8 percent vs 48.8 percent; p<0.001).

A total of 357 participants survived to the 90-day follow-up, yielding a short-term survival rate of 82.1 percent. Those who were younger were more likely to survive (median, 47 years vs 61 years; p<0.001). Pancreatitis was the most common underlying cause of death (98.7 percent; n=77).

Stratifying participants according to age groups further highlighted the survival benefit of younger age. The survival rate was 89.5 percent in those <60 years of age and dropped progressively to 60.3 percent and 43.3 percent in patients 60–69 years and 70 years, respectively.

For long-term outcomes, participants were followed for a median of 5.8 years. The resulting 10-year survival estimates were 28.3 percent and 67.9 percent for those older and younger than 60 years, respectively.

Alcohol-related reasons accounted for more than half of the long-term deaths (57.1 percent; n=48). These included any underlying or immediate alcohol-related diseases, alcohol intoxication, and traumatic deaths associated with alcohol use. Acute pancreatitis was the cause of death in 22 (26.2 percent) late mortalities.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.