Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
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Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.

Air pollution ups risk of death after heart transplantation

16 Dec 2019

Ambient air pollution is associated with mortality in patients who underwent heart transplantation, claims a recent study.

Of the 21,800 heart transplant recipients (mean age at transplantation, 52.6±12.6 years) with 86,713 patient-years of follow-up, 75 percent were male, 69 percent were white, and 39 percent had ischaemic aetiology of heart failure. Mean annual exposure to fine particulate matter concentrations (particles with diameter <2.5 μm [PM2.5]; 1 × 1-km grids) was 10.6±2.3 μg/m3.

A total of 5,208 patients (23.9 percent) had died at a median follow-up of 4.8 years (95 percent confidence interval [CI], 2.0–7.8).

The estimated mortality hazard ratio per 10-μg/m3 increment increase in annual PM2.5 exposure was 1.43 (95 percent CI, 1.21–1.49), and this slightly dropped to 1.26 (95 percent CI, 1.11–1.43) after adjusting for 30 recipient, donor and neighbourhood variables. Such association persisted across subgroups.

“These results suggest an important influence of a key environmental factor in outcomes following heart transplantation and support the need for further studies in this population,” the authors said.

This study linked mortality data in heart transplant recipients in the United Network for Organ Sharing (UNOS) database, on the basis of the zip code of residence, to validated estimates of PM2.5 for each calendar year during which a UNOS cardiac transplant recipient was at risk for death. The association between exposure to air pollution and overall mortality was estimated using Cox proportional hazard models, adjusting for recipient, donor and neighbourhood variables.

“Heart transplant recipients are at high risk for mortality, with traditional risk scores performing modestly in predicting post-transplant survival, underscoring the importance of as yet unidentified factors in determining prognosis,” the authors noted.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.