Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Air pollution ups death risk in general population

26 Apr 2020
Air Pollution beyond COPD & asthma: Linked to increased cancer mortality

Long-term exposure to air pollution exacerbates mortality risk in the general population, a recent Korea study has found.

The study included 436,933 participants (mean age, 47.8 years; 50.1 percent male) whose residential addresses were matched to hourly measurements of PM2.5 concentration data. All-cause and cardiovascular mortality rates were measured according to pollutant exposure.

Over 1,683,271 person-years of follow-up, 382 and 95 all-cause and cardiovascular deaths were reported, respectively. Daily PM2.5 levels ranged from 10–45 µg/m3 for most of the measurement days.

Cox proportional hazards models each 10-µg/m3 increase in PM2.5 correlated with a significant increase in the risk of all-cause (hazard ratio [HR], 1.034, 95 percent confidence interval [CI], 1.027–1.041; p<0.001) and cardiovascular (HR, 1.047, 95 percent CI, 1.036–1.058; p<0.001) mortality. Notably, the relationship of PM2.5 concentrations >18.0 µg/m3 with mortality risk was almost linear.

Receiver operating characteristic curve analysis found that PM2.5 was a good predictor of both all-cause and cardiovascular mortality, with c-index values of 0.82 and 0.85, respectively.

The principal findings were robust to subgroup analyses, though researchers found that those with previous myocardial infarction were significantly more susceptible to the effects of PM2.5 on all-cause mortality risk (pinteraction=0.018). There was also a nonsignificantly stronger effect among men and those who had a history of atrial fibrillation, heart failure and stroke.

“Our study supports a small but significant association between PM2.5 and both all-cause or cardiovascular mortality, which may be a modifiable risk factor in our study population,” the researchers said. “Additionally, our study demonstrated the specific PM2.5 concentration for further raising these mortalities which had not been well-studied previously.”

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.