Most Read Articles
01 May 2014

New drug applications approved by US FDA as of 15-30 May which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

28 Apr 2017
Silymarin does not appear to be significantly better than placebo in reducing disease activity by 30 percent or more in patients with nonalcoholic steatohepatitis (NASH), according to the results of a trial.
08 May 2017
Transabdominal bowel wall ultrasonography shows utility in monitoring disease activity in patients with active Crohn’s disease (CD), according to a study. The imaging technique is ideal for evaluating early transmural changes in disease activity, in response to medical treatment.

Aggressive hydration with lactated Ringer solution prevents post-ERCP pancreatitis

01 Sep 2017

The overall incidence of postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP), moderate to severe pancreatitis and hyperamylasaemia can be reduced by aggressive hydration with lactated Ringer solution, suggests a recent study.

In addition, aggressive hydration with lactated Ringer solution may also shorten the length of hospital stay as well as reduce pain.

Researchers performed a systematic review and meta-analysis of randomized controlled trials (RCTs) published before March 2017 to assess the clinical effectiveness and safety of aggressive hydration with lactated Ringer solution preventing PEP.

All relevant articles were accessed from PubMed, the Cochrane Library, Embase, the Web of Science, ClinicalTrial.gov and Scopus database. Reference lists from reviews or relevant articles were screened for RCTs.

The incidence of PEP and the incidence of moderate to severe pancreatitis were the primary outcomes, and the secondary outcomes were the incidence of hyperamylasaemia and pain and the length of hospitalization. The Cochrane Program Review Manager was used to perform the meta-analysis.

A total of three RCTs were included in the study. The meta-analysis revealed that patients who underwent aggressive hydration with lactated Ringer solution had a lower incidence of pancreatitis after ERCP (odds ratio [OR], 0.29; 95 percent CI, 0.16 to 0.53), moderate to severe PEP (OR, 0.16; 0.03 to 0.96) and hyperamylasaemia (OR, 0.38; 0.25 to 0.59).

Furthermore, the aggressive hydration group had a lower risk of pain (OR, 0.17; 0.08 to 0.38) and a shorter duration of hospitalization (standardized mean difference=‒0.41; ‒0.69 to ‒0.14).

“As shown in studies, aggressive hydration during the perioperative period of ERCP effectively prevents PEP,” according to researchers. 

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Most Read Articles
01 May 2014

New drug applications approved by US FDA as of 15-30 May which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

28 Apr 2017
Silymarin does not appear to be significantly better than placebo in reducing disease activity by 30 percent or more in patients with nonalcoholic steatohepatitis (NASH), according to the results of a trial.
08 May 2017
Transabdominal bowel wall ultrasonography shows utility in monitoring disease activity in patients with active Crohn’s disease (CD), according to a study. The imaging technique is ideal for evaluating early transmural changes in disease activity, in response to medical treatment.