Most Read Articles
Roshini Claire Anthony, 23 Nov 2017

The long-term mortality benefit conferred by mechanical over biologic prosthesis in valve replacement appears to be age- and location-dependent, according to findings of a US-based retrospective study.  

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Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
Pearl Toh, 5 days ago
The protective effects of liraglutide against the risks of cardiovascular (CV) events and deaths may be reduced in patients with type 2 diabetes (T2D) who experienced severe hypoglycaemia, but were independent of patient’s history of CV events at baseline, according to post hoc analyses of the LEADER* trial.
01 Aug 2015
A higher prevalence of coronary artery disease was reported among adult men than women with Kawasaki disease, a study shows.

Age alters relation between cognitive function, intraindividual variability in BP

3 days ago

Intraindividual measurement-to-measurement variation in blood pressure (BP IIV) significantly predicts cognition with advancing age, a study has found.

There was a significant age by BP IIV interaction, according to the investigators.

Among individuals aged >60 years, IIV in systolic (SBP) and diastolic blood pressure (DBP) had an inverse association with Global Composite, Scanning and Tracking and the Similarities test. In addition, IIV in SBP correlated with Verbal Memory and the Mini-Mental State Examination. Furthermore, IIV in DBP was associated with the Visual-Spatial Memory and Organization composite.

No significant associations were observed between BP IIV and cognitive function in individuals aged <60 years.

In one study, researchers found that higher overall variability in both SBP and DBP was associated with poorer cognitive performance in unsuccessfully treated hypertensive individuals (with BP ≥140/90 mm Hg). However, these associations were not evident in those with controlled hypertension. [Hypertension 2014;64:1094-1101]

The present study aimed to assess age by BP IIV (SBP and DBP) interactions vis-à-vis cognitive functioning while considering medication class and polypharmacy, which might also affect BP IIV with advancing age.

A total of 980 community-dwelling individuals from the Maine-Syracuse Longitudinal Study were included in the cross-sectional analyses. Automated BP measures were taken 15 times (five times each in sitting, reclining and standing positions). A thorough neuropsychological test battery was used after the BP assessment to examine cognitive function.

“There is evidence to suggest that BP IIV may be superior to mean BP for predicting cognitive function, taken from both within a single visit and between-visits,” the investigators noted. “BP IIV increases with age in studies of persons middle-aged and older.”

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Most Read Articles
Roshini Claire Anthony, 23 Nov 2017

The long-term mortality benefit conferred by mechanical over biologic prosthesis in valve replacement appears to be age- and location-dependent, according to findings of a US-based retrospective study.  

10 Jan 2018
Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
Pearl Toh, 5 days ago
The protective effects of liraglutide against the risks of cardiovascular (CV) events and deaths may be reduced in patients with type 2 diabetes (T2D) who experienced severe hypoglycaemia, but were independent of patient’s history of CV events at baseline, according to post hoc analyses of the LEADER* trial.
01 Aug 2015
A higher prevalence of coronary artery disease was reported among adult men than women with Kawasaki disease, a study shows.