Most Read Articles
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.

Age, sex do not affect outcomes after PCI, CABG

23 Aug 2019

Age and sex do not appear to influence outcomes after percutaneous coronary intervention (PCI) or coronary-artery bypass grafting (CABG) for left main coronary artery (LMCA) disease, reports a recent study.

The study included 4,001 LMCA patients who underwent either PCI (n=2,615; mean age, 63.7±10.8 years; 77.3 percent male) or CABG (n=1,386; mean age, 64.6±9.1 years; 77.8 percent male) for treatment. Participants were divided according to tertiles of age (<60, 60–69, 70 years) and according to sex. The primary outcome was a composite of death from any cause, stroke or myocardial infarction.

Over a median follow-up of 6.3 years, the primary composite endpoint occurred significantly more frequently in patients who received CABG vs PCI (14.5 percent vs 10.8 percent; p=0.001). This was also true in males (15.0 percent vs 11.0 percent; p=0.002) but not in females (12.8 percent vs 10.1 percent; p=0.17).

The difference in incidence of the primary outcome was only significant in participants aged <60 years (CABG vs PCI: 7.7 percent vs 4.0 percent; p=0.009).

However, multivariable Cox regression analysis found that there was no significant difference in the risk of the primary composite outcome between the PCI and CABG groups (adjusted hazard ratio [HR], 0.94, 95 percent CI, 0.75–1.16; p=0.55). This remained consistent across all age groups examined (p-interaction=0.57).

Stratifying according to sex likewise yielded meaningful changes. The risk of the primary outcome was comparable between PCI and CABG in both males (adjusted HR, 0.92, 0.72–1.17; p=0.47) and females (adjusted HR, 0.89, 0.52–1.50; p=0.65; p-interaction with sex=0.65).

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Most Read Articles
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.