Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Advanced inflammation a red flag for gallstone disease

11 Oct 2020

Elevated high-sensitivity C-reactive protein levels (hs-CRP) appear to contribute to an increased risk of gallstone disease, as reported in a study.

Researchers followed a cohort of 95,319 individuals (mean age, 50.78 years; 78.83 percent male) residing in Tangshan City in northern China. Those with higher hs-CRP concentrations (1–3 and >3 mg/L vs <1 mg/L) were older, had larger waist circumference, and higher blood pressure, total cholesterol, fasting blood glucose, and white blood cell count.

Over a mean follow-up of 7.58 years, 4,205 developed gallstones, some of whom underwent cholecystectomy. The age- and sex-standardized overall incidence of gallstone disease was 6.99 per 1,000 person-years.

There was a positive association between hs-CRP and incident gallstone disease. The incidence rates were 5.96 per 1,000 person-years among individuals with hs-CRP <1 mg/L, 7.99 per 1,000 person-years among those with hs-CRP 1–3 mg/L, and 9.13 per 1,000 person-years among those with hs-CRP >3 mg/L.

Cox proportional hazards regression models showed that compared with the lowest tertile of hs-CRP concentration, the higher tertiles were associated with 11–12-percent increased risk of gallstone disease (1–3 mg/L: hazard ratio [HR], 1.11, 95 percent confidence interval [CI], 1.03–1.19; >3 mg/L: HR, 1.12, 95 percent CI, 1.04–1.22).

The inclusion of hs-CRP in the multivariate model (which consisted of age, sex, body mass index, total cholesterol, triglyceride, alanine aminotransferase, smoking status, drinking status, diabetes mellitus, hypertension, and physical activity) for identifying new cases of gallstone disease not only had a better line of fitness (according to the Akaike information criterion) but also had better accuracy.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).