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Pearl Toh, 22 Oct 2020
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Advanced inflammation a red flag for gallstone disease

11 Oct 2020

Elevated high-sensitivity C-reactive protein levels (hs-CRP) appear to contribute to an increased risk of gallstone disease, as reported in a study.

Researchers followed a cohort of 95,319 individuals (mean age, 50.78 years; 78.83 percent male) residing in Tangshan City in northern China. Those with higher hs-CRP concentrations (1–3 and >3 mg/L vs <1 mg/L) were older, had larger waist circumference, and higher blood pressure, total cholesterol, fasting blood glucose, and white blood cell count.

Over a mean follow-up of 7.58 years, 4,205 developed gallstones, some of whom underwent cholecystectomy. The age- and sex-standardized overall incidence of gallstone disease was 6.99 per 1,000 person-years.

There was a positive association between hs-CRP and incident gallstone disease. The incidence rates were 5.96 per 1,000 person-years among individuals with hs-CRP <1 mg/L, 7.99 per 1,000 person-years among those with hs-CRP 1–3 mg/L, and 9.13 per 1,000 person-years among those with hs-CRP >3 mg/L.

Cox proportional hazards regression models showed that compared with the lowest tertile of hs-CRP concentration, the higher tertiles were associated with 11–12-percent increased risk of gallstone disease (1–3 mg/L: hazard ratio [HR], 1.11, 95 percent confidence interval [CI], 1.03–1.19; >3 mg/L: HR, 1.12, 95 percent CI, 1.04–1.22).

The inclusion of hs-CRP in the multivariate model (which consisted of age, sex, body mass index, total cholesterol, triglyceride, alanine aminotransferase, smoking status, drinking status, diabetes mellitus, hypertension, and physical activity) for identifying new cases of gallstone disease not only had a better line of fitness (according to the Akaike information criterion) but also had better accuracy.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.