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Advanced COPD tied to reduced BMI, hand grip strength, respiratory function

05 Oct 2020

Advanced stages of chronic obstructive pulmonary disease (COPD) are associated with significantly lower body mass index (BMI), fat-free body mass, hand grip strength, and respiratory and skeletal muscle functions, reports a recent study.

COPD patients aged ≥40 years who were followed for at least 1 year were included in this prospective observational study, which sought to assess nutritional statuses of COPD patients in four categories of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015 classification, as well as evaluate associations of BMI and fat-free mass index with respiratory and skeletal muscle strengths.

The authors recorded the patients’ medical histories, smoking status, and anthropometric, spirometry, and hand grip strength measurements.

A total of 463 COPD patients were included and classified according to GOLD as follows: group A (n=119), group B (n=58), group C (n=117), and group D (n=169). Patients in group D were older than those in other groups (p=0.001). No between-group difference was found in terms of sex (p=0.163).

Group D had significantly reduced fat-free body mass compared with group A (p=0.014). BMI was also lower in groups C and D than in other groups (p=0.001). In addition, a significant decreasing trend in spirometry and hand grip strength was observed toward group D (p<0.001 for both).

“Nutritional status should be routinely monitored and considered an important indicator in COPD,” the authors said.

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Most Read Articles
3 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
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Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).