Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.

ADT-AAP combo effective for mHNPC independent of risk stratification

20 Nov 2019

The combination of androgen deprivation therapy (ADT) with abiraterone acetate and prednisolone (AAP) treatment is effective against metastatic hormone-naïve prostate cancer (mHNPC) regardless of risk stratification, a recent study has shown.

Researchers performed a posthoc subgroup analysis of the STAMPEDE trial, including 901 participants, of whom 428 were defined as low-risk, while the remaining 473 were high-risk. The primary outcome was overall survival (OS), while secondary outcome was failure-free survival (FFS).

In the low-risk criteria, 220 received ADT alone, while 208 were treated with both ADT and AAP. In the high-risk group, 232 received monotreatment while 241 received the combination therapy.

A total of 330 deaths were reported. Absolute 3-year survival rates were significantly better in low-risk patients given the combination therapy (83 percent vs 78 percent; hazard ratio [HR], 0.66, 95 percent confidence intervals [CI], 0.44–0.98). The same was true for the high-risk group (65 percent vs 45 percent; HR, 0.54, 95 percent CI, 0.41–0.70).

Similar effects were reported for the secondary outcomes. In low-risk patients, 3-year FFS showed a 44-percent absolute improvement after ADT+AAP relative to ADT alone (76 percent vs 32 percent; HR, 0.25, 95 percent CI, 0.17–0.33). The magnitude of difference decreased in high-risk patients, but nevertheless remained significant (45 percent vs 12 percent; HR, 0.31, 95 percent CI, 0.25–0.39).

The present findings support the use of ADT and AAP for mHNPC independent of risk stratification, said the researchers.

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.