Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Jairia Dela Cruz, 03 May 2018
Acute coronary syndrome (ACS) patients with diabetes mellitus, as well as high-risk nondiabetic patients, appear to obtain significant cardioprotection from the addition of ezetimibe to simvastatin, and this benefit is achieved without compromising safety, according to an exploratory analysis of data from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

Adrenalectomy reduces risk of new-onset diabetes mellitus, all-cause mortality

28 Jul 2017

Patients with primary aldosteronism who underwent adrenalectomy have lower risk of incident new-onset diabetes mellitus (NODM) and all-cause mortality than matched hypertensive controls, according to a recent study.

Researchers identified patients diagnosed with primary aldosteronism and essential hypertension. They then used a validated algorithm from a 23-million population insurance registry to ascertain the occurrence of NODM and all-cause mortality among the participants.

A total of 2,367 primary aldosteronism patients without previous DM were identified and propensity score-matched with 9,468 patients with essential hypertension from 1999 to 2007. Among primary aldosteronism patients, 754 who had aldosterone-producing adenomas were identified and matched with 3,016 essential hypertension controls.

Compared with essential hypertension controls, primary aldosteronism patients who underwent adrenalectomy had reduced incidence of NODM (hazard ratio [HR], 0.60; p<0.01), while those treated with mineralocorticoid receptor antagonist had increased risk of NODM (HR, 1.16; p<0.001) over a mean follow-up of 5.2 years.

Furthermore, adrenalectomy was protective against the development of NODM among aldosterone-producing adenoma patients (HR, 0.61; p<0.001), but treatment with mineralocorticoid receptor antagonist did not alter the risk of NODM (p=0.10).

Adjusted HRs for long-term risk of mortality from this analysis demonstrated that adrenalectomy was protective but NODM and major cardiovascular disease were harmful.

“This observation adds more evidence on the association of primary aldosteronism with a higher risk of metabolic syndrome and long-term mortality,” researchers said, adding that abnormal glucose metabolism due to insulin resistance has been linked to overproduction of aldosterone.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Jairia Dela Cruz, 03 May 2018
Acute coronary syndrome (ACS) patients with diabetes mellitus, as well as high-risk nondiabetic patients, appear to obtain significant cardioprotection from the addition of ezetimibe to simvastatin, and this benefit is achieved without compromising safety, according to an exploratory analysis of data from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).