Most Read Articles
Roshini Claire Anthony, 3 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Yesterday
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
2 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Adrenalectomy, MRA improve QoL in primary aldosteronism

10 Feb 2018

Both surgical (adrenalectomy) and medical (mineralocorticoid receptor antagonists [MRA]) treatments improve quality of life (QoL) in primary aldosteronism (PA), which highlights the importance of identifying these patients, according to a recent study.

In addition, better improvement in QoL is observed after adrenalectomy for suspected aldosterone-producing adenoma (APA) than after initiation of medical treatment for suspected bilateral adrenal hyperplasia (BAH). APA and BAH are two subtypes of PA.

A total of 184 patients with PA were included in this posthoc comparative effectiveness study within the Subtyping Primary Aldosteronism: A Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan (SPARTACUS) trial. QoL was assessed at baseline and 6- and 1-year follow-up using two validated questionnaires: RAND 36-item Health Survey (RAND SF-36) and European Quality of Life‒5 Dimensions (EQ-5D).

Patients with PA, compared with the general population, had lower scores in seven of eight RAND SF-36 and both summary scores, as well as in three of five EQ-5D dimensions and the visual analogue scale at baseline.

Adrenalectomy demonstrated larger beneficial effects than those for MRAs for seven RAND SF-36 subscales, both summary scores and health change. For the EQ-5D, there was a difference in favour of adrenalectomy in two dimensions and the visual analogue scale.

In both surgical and medical treatments, most differences in QoL exceeded the minimally clinically important difference. After 1 year, almost all QoL measures had normalized for patients who underwent adrenalectomy. For those on MRAs, most QoL measures had improved but not all to the level of the general population.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Yesterday
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
2 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.