Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Adrenal suppression may occur in infants treated with topical ocular glucocorticoids

05 Oct 2018

Adrenal suppression is present in two-thirds of infants tested during treatment with a standard glucocorticoid (GC) protocol after congenital cataract surgery, according to a recent study, noting a significant association between cumulative daily dose of GCs and the test result.

Fifteen (58 percent) of 26 consecutive infants were tested while still on GC treatment. Of these, 10 (67 percent) had adrenal suppression, two of whom had obvious clinical signs of Cushing’s syndrome and one of whom had signs of Addisonian crises during general anaesthesia.

Of the 26 infants, 11 (42 percent) were tested at a median time of 21 days (range, 6–89) after treatment cessation. All had normal test results.

Children with adrenal suppression were given cumulative GC doses per body weight that were significantly higher the last 5 days prior to testing vs those with normal test results. Infants with suppressed adrenal function received hydrocortisone replacement therapy and recovered after a median of 3.1 months (range, 2.3 months to 2.3 years).

“Because adrenal suppression is a serious but treatable condition, we recommend a systematic assessment of adrenal function in infants treated with doses of topical ocular GCs comparable to our regimen and careful evaluations of other treatment regimens,” the investigators said.

In this retrospective, consecutive case series, all children aged <2 years who underwent operation for congenital cataract between January 2011 and May 2015 in one centre were included. The investigators reviewed patients charts to obtain data on results and timing of a standard corticotropin (adrenocorticotropic hormone) stimulation test and GC dose per kilogram body weight.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.