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Admissions for acute myocardial infarction with rheumatoid arthritis on the rise

07 Oct 2020

While hospitalizations are on the rise for acute myocardial infarction (AMI) patients with rheumatoid arthritis, rates of in-hospital mortality seem to be decreasing, a new study has found.

Drawing from the National Inpatient Sample database of the US, researchers identified 9,359,546 hospitalizations due to AMI. The main outcome of interest was the temporal change in AMI hospitalizations with rheumatoid arthritis, as well as in-hospital mortality in this population. Other endpoints included cardiac arrest and mechanical circulatory support use.

Among all AMI hospitalizations, 123,783 (1.3 percent) had concurrent rheumatoid arthritis. A further 30.9 percent (n=38,815) of this subpopulation had ST-elevation myocardial infarction (STEMI).

From 2002 to 2016, researchers documented an increase in the number of AMI hospitalizations with rheumatoid arthritis, jumping from 6,730 to 10,829 (ptrend<0.001). This coincided with a significant downtrend in the hospitalizations for AMI without rheumatoid arthritis (ptrend=0.01).

Despite a ballooning hospitalization rate, AMI-rheumatoid arthritis patients seemed to enjoy improving outlook: rates of percutaneous coronary intervention grew (28.2 percent to 41.6 percent; ptrend<0.001), leading to a declining in-hospital mortality rate (5.8 percent vs 5.2 percent; ptrend=0.01).

Fully adjusted multivariable regression analysis revealed that rheumatoid arthritis was significantly protective against mortality risk in AMI patients (odds ratio, 0.90, 95 percent confidence interval, 0.81–0.99; p=0.03).

“Further studies are needed to evaluate the long-term outcomes of AMI among patients with rheumatoid arthritis,” researchers said.

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Most Read Articles
2 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
Yesterday
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 5 days ago
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).