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Admissions for acute myocardial infarction with rheumatoid arthritis on the rise

07 Oct 2020

While hospitalizations are on the rise for acute myocardial infarction (AMI) patients with rheumatoid arthritis, rates of in-hospital mortality seem to be decreasing, a new study has found.

Drawing from the National Inpatient Sample database of the US, researchers identified 9,359,546 hospitalizations due to AMI. The main outcome of interest was the temporal change in AMI hospitalizations with rheumatoid arthritis, as well as in-hospital mortality in this population. Other endpoints included cardiac arrest and mechanical circulatory support use.

Among all AMI hospitalizations, 123,783 (1.3 percent) had concurrent rheumatoid arthritis. A further 30.9 percent (n=38,815) of this subpopulation had ST-elevation myocardial infarction (STEMI).

From 2002 to 2016, researchers documented an increase in the number of AMI hospitalizations with rheumatoid arthritis, jumping from 6,730 to 10,829 (ptrend<0.001). This coincided with a significant downtrend in the hospitalizations for AMI without rheumatoid arthritis (ptrend=0.01).

Despite a ballooning hospitalization rate, AMI-rheumatoid arthritis patients seemed to enjoy improving outlook: rates of percutaneous coronary intervention grew (28.2 percent to 41.6 percent; ptrend<0.001), leading to a declining in-hospital mortality rate (5.8 percent vs 5.2 percent; ptrend=0.01).

Fully adjusted multivariable regression analysis revealed that rheumatoid arthritis was significantly protective against mortality risk in AMI patients (odds ratio, 0.90, 95 percent confidence interval, 0.81–0.99; p=0.03).

“Further studies are needed to evaluate the long-term outcomes of AMI among patients with rheumatoid arthritis,” researchers said.

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Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, Yesterday
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