Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Adjuvant CXL may worsen vision in patients with moderate fungal keratitis

25 Jan 2020

Treatment with adjuvant corneal cross-linking (CXL) does not seem to produce favourable results in patients with moderate filamentous fungal ulcers and may even lead to reduced visual acuity, a recent study has shown.

Consecutive patients presenting with moderate vision loss from a smear-positive fungal ulcer at Aravind Eye Hospital in Madurai, India, were included in this outcome-masked, two-by-two factorial design, randomized controlled trial.

Study eyes were randomly assigned to one of four treatment combinations using an adaptive randomization protocol. Treatment arms were as follows: topical natamycin 5% alone, topical natamycin 5% plus CXL, topical amphotericin B 0.15% alone, and topical amphotericin 0.15% plus CXL.

Patients who received CXL, irrespective of medication (topical natamycin or amphotericin), showed 1.32-fold higher odds of 24-hour culture positivity, albeit statistically nonsignificant (95 percent confidence interval [CI], 0.57–3.06; p=0.51). There was also no difference found in 24-hour culture positivity between patients on amphotericin and those on natamycin when evaluating as a group regardless of whether they received CXL or not (coefficient, 1.10, 95 percent CI, 0.47–2.54; p=0.84).

Among patients receiving CXL regardless of medication, the best spectacle-corrected visual acuity (BSCVA) was approximately 0.22 logMAR (2.2 Snellen lines) worse on average at 3 weeks and 0.32 logMAR (3.2 Snellen lines) worse at 3 months after controlling for baseline visual acuity (95 percent CI, 0.03–0.54; p=0.02).

When comparing CXL with no CXL or the two topical medications, no difference was observed in infiltrate or scar size, percentage of epithelialized or adverse events.

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Editor's Recommendations
Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.