Most Read Articles
Pearl Toh, 6 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Adjuvant CXL may worsen vision in patients with moderate fungal keratitis

25 Jan 2020

Treatment with adjuvant corneal cross-linking (CXL) does not seem to produce favourable results in patients with moderate filamentous fungal ulcers and may even lead to reduced visual acuity, a recent study has shown.

Consecutive patients presenting with moderate vision loss from a smear-positive fungal ulcer at Aravind Eye Hospital in Madurai, India, were included in this outcome-masked, two-by-two factorial design, randomized controlled trial.

Study eyes were randomly assigned to one of four treatment combinations using an adaptive randomization protocol. Treatment arms were as follows: topical natamycin 5% alone, topical natamycin 5% plus CXL, topical amphotericin B 0.15% alone, and topical amphotericin 0.15% plus CXL.

Patients who received CXL, irrespective of medication (topical natamycin or amphotericin), showed 1.32-fold higher odds of 24-hour culture positivity, albeit statistically nonsignificant (95 percent confidence interval [CI], 0.57–3.06; p=0.51). There was also no difference found in 24-hour culture positivity between patients on amphotericin and those on natamycin when evaluating as a group regardless of whether they received CXL or not (coefficient, 1.10, 95 percent CI, 0.47–2.54; p=0.84).

Among patients receiving CXL regardless of medication, the best spectacle-corrected visual acuity (BSCVA) was approximately 0.22 logMAR (2.2 Snellen lines) worse on average at 3 weeks and 0.32 logMAR (3.2 Snellen lines) worse at 3 months after controlling for baseline visual acuity (95 percent CI, 0.03–0.54; p=0.02).

When comparing CXL with no CXL or the two topical medications, no difference was observed in infiltrate or scar size, percentage of epithelialized or adverse events.

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Most Read Articles
Pearl Toh, 6 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.