Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.

Adjunctive VNS delivers better outcomes than treatment as usual in moderate to severe depression

10 Jul 2017
One in three Malaysians is struggling with mental health issues

Adjunctive vagus nerve stimulation (VNS) improves long-term outcomes compared with treatment as usual in patients with treatment-resistant depression, reports a recent study.

Researchers conducted a 5-year, prospective, open-label, nonrandomized, observational registry study at 61 US sites, which included 795 patients who were experiencing a major depressive episode (unipolar or bipolar depression) of at least 2 years’ duration or had three or more depressive episodes (including the current one), and who had failed four or more depression treatments (including electroconvulsive therapy [ECT]). Those with a history of psychosis or rapid-cycling bipolar disorder were excluded.

Response rate, defined as a decrease of ≥50 percent in baseline Montgomery-Åsberg Depression Rating Scale (MADRS) score at any postbaseline visit during the study period, was the primary efficacy measure. Secondary efficacy measures included remission.

Patients were diagnosed with chronic moderate to severe depression at baseline (mean MADRS scores, 29.3 for the treatment-as-usual group and 33.1 for the adjunctive VNS group).

Better clinical outcomes were observed in the adjunctive VNS group compared with the treatment-as-usual group. Moreover, the adjunctive VNS group had a significantly higher 5-year cumulative response rate (67.6 vs 40.9 percent) and a significantly greater remission rate (cumulative first-time remitters, 43.3 vs 25.7 percent).

In a subanalysis, patients with a history of response to ECT included in the adjunctive VNS group had a significantly higher 5-year cumulative response than those in the treatment-as-usual group (71.3 vs 56.9 percent). There was a similar significant response differential among ECT nonresponders (59.6 vs 34.1 percent).

“This registry represents the longest and largest naturalistic study of efficacy outcomes in treatment-resistant depression, and it provides additional evidence that adjunctive VNS has enhanced antidepressant effects compared with treatment as usual in this severely ill patient population,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Psychiatry - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.