Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.

Adjunctive perampanel efficacy, safety in epilepsy hold up over long-term assessment

29 Jul 2020

Adjunctive perampanel appears to be safe and effective for long-term treatment of patients with tonic‐clonic seizures, according to a posthoc analysis.

The analysis included patients with focal to bilateral tonic‐clonic seizures (FBTCS; n=720) or generalized tonic‐clonic seizures (GTCS; n=138) aged 12 years who participated in four open‐label extension (OLEx) studies. These patients received adjunctive perampanel (up to 12 mg/d) for up to 4 years.

In the FBTCS and GTCS groups, mean ages were 32.5 and 27.9 years, respectively, and 48.9 percent and 57.3 percent were women. Mean cumulative duration of perampanel exposure was 102.3 weeks in the FBTCS group and 83.9 weeks in the GTCS group. Retention rates were 50.0 percent for up to 4 years in the former and 49.2 percent for up to 2 years in the latter.

Across OLEx treatment durations, seizure frequency per 28 days decreased by a median of 66.7 percent in the FBTCS group and by 80.6 percent in the GTCS group. In the former, 59.5 percent, 45.3 percent, and 18.4 percent of the patients achieved 50-percent and 75-percent responses and freedom from seizure, respectively. The corresponding numbers in the GTCS group were 72.5 percent, 51.5 percent, and 16.7 percent.

The beneficial effects persisted for up to 4 years for FBTCS and up to 3 years for GTCS, even when accounting for early dropouts.

Treatment-emergent adverse event (TEAE) rates were the highest during year 1, occurring in 85.3 percent in the FBTCS group and 86.2 percent in the GTCS group; the most common were dizziness and somnolence. Eighty-one (11.3 percent) and 10 (7.2 percent) patients in the respective groups developed serious TEAEs. The reported TEAEs were consistent with the known safety profile of perampanel, and no new safety signals emerged with long‐term treatment.

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Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.