Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
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17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 4 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.

Adjunctive bismuth yields high H. pylori eradication rates

07 May 2019

Adding bismuth to a 14-day course of standard triple therapy with clarithromycin and amoxicillin leads to a high rate of Helicobacter pylori infection eradication, with an acceptable safety profile and level of adherence, according to a study.

Researchers performed an interim analysis of data from the European Registry on H pylori Management. The analysis included 1,141 treatment-naïve patients who received first-line treatment with bismuth salts 240 mg plus a proton pump inhibitor (57 percent received esomeprazole, 18 percent omeprazole, 11 percent pantoprazole and 14 percent rabeprazole), amoxicillin 1 g and clarithromycin 500 mg, all administered twice daily.

Eradication rates were 88 percent in the intention-to-treat analysis and 94 percent in the per-protocol analysis. The intention-to-treat eradication rate notably increased to 93 percent in patients who received 14-day treatments.

Adverse events occurred in 36 percent of patients. Majority (76 percent) of the reported events were mild, with a mean duration of 6 days.

Multivariate models revealed eradication to be associated with treatment compliance (odds ratio [OR], 13.0), use of a double dose of proton pump inhibitor (equivalent to 40-mg omeprazole; OR, 4.7) and 14-day duration of treatment (OR, 2.0).

According to researchers, the addition of bismuth salts has been proposed for first-line eradication of H. pylori infection due to the poor eradication rates of standard triple therapy. The present data show that such a strategy yields high eradication rates.

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Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 4 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.