Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).

Adjunctive bismuth yields high H. pylori eradication rates

07 May 2019

Adding bismuth to a 14-day course of standard triple therapy with clarithromycin and amoxicillin leads to a high rate of Helicobacter pylori infection eradication, with an acceptable safety profile and level of adherence, according to a study.

Researchers performed an interim analysis of data from the European Registry on H pylori Management. The analysis included 1,141 treatment-naïve patients who received first-line treatment with bismuth salts 240 mg plus a proton pump inhibitor (57 percent received esomeprazole, 18 percent omeprazole, 11 percent pantoprazole and 14 percent rabeprazole), amoxicillin 1 g and clarithromycin 500 mg, all administered twice daily.

Eradication rates were 88 percent in the intention-to-treat analysis and 94 percent in the per-protocol analysis. The intention-to-treat eradication rate notably increased to 93 percent in patients who received 14-day treatments.

Adverse events occurred in 36 percent of patients. Majority (76 percent) of the reported events were mild, with a mean duration of 6 days.

Multivariate models revealed eradication to be associated with treatment compliance (odds ratio [OR], 13.0), use of a double dose of proton pump inhibitor (equivalent to 40-mg omeprazole; OR, 4.7) and 14-day duration of treatment (OR, 2.0).

According to researchers, the addition of bismuth salts has been proposed for first-line eradication of H. pylori infection due to the poor eradication rates of standard triple therapy. The present data show that such a strategy yields high eradication rates.

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Most Read Articles
30 Nov 2018
New drug applications approved by US FDA as of 16 - 30 November 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 days ago

A combination of tocilizumab and methotrexate reduced disease activity at 2 years compared with methotrexate plus prednisone in patients with early rheumatoid arthritis (RA), an effect not demonstrated with tocilizumab monotherapy.

Roshini Claire Anthony, 2 days ago

The use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) did not increase a woman’s risk of acquiring HIV compared with the use of a copper intrauterine device (IUD) or a levonorgestrel implant, results of a study conducted by the ECHO* Trial Consortium show.

14 May 2019
At the recent GLYCEMIC GUARDIANS™ dinner symposium, three eminent speakers spoke on theindispensable role of medical nutrition therapy (MNT) in improving outcomes for patients with type2 diabetes (T2D).