Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 6 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
Roshini Claire Anthony, 3 days ago

The combination of ceftazidime and avibactam proved noninferior to meropenem in adults with nosocomial pneumonia, positioning it as a potential treatment option for this condition, results from the phase III REPROVE* trial show. Nonetheless, the combination was associated with a higher number of safety events compared with meropenem.

Adiponectin ups risk of proteinuria in lupus

23 Sep 2017
Kidney failures and organ donors: Singapore

Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

In the study cohort of 103 female SLE patients (mean age 43 years), the levels of adiponectin and the adiponectin to body mass index (BMI) ratio were both significantly higher than in the control group (n=83; p<0.001).

In contrast, leptin levels (p=0.09) and leptin to BMI ratio (p=0.08) were only marginally significantly higher in the SLE patients compared with controls.

The SLE patients were further divided into two according to renal activity status: those with (n=30) and those without (n=73) proteinuria.

Both adiponectin levels (20.4 vs 15.6 µg/mL; p=0.02) and adiponectin to BMI ratio (0.8 vs 0.6; p=0.02) were significantly higher in patients with proteinuria than in SLE patients without renal involvement. Again, leptin levels and the leptin to BMI ratio were only marginally higher in those with proteinuria.

Serum adiponectin levels were also significantly correlated with a high degree of proteinuria (p=0.001) and high SLE disease activity index (SLEDAI; p=0.05) and renal-SLEDAI (p=0.002) scores. Serum creatinine (p=0.05) and corticosteroid dose (p=0.03) were also significantly associated with serum adiponectin.

Logistic regression analysis showed that the risk of proteinuria in SLE patients was significantly higher in those with higher level of adiponectin (odds ratio, 1.06; 95 percent CI, 1.01 to 1.12; p=0.02). Serum leptin levels did not significantly affect the risk of proteinuria.

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Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 6 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
Roshini Claire Anthony, 3 days ago

The combination of ceftazidime and avibactam proved noninferior to meropenem in adults with nosocomial pneumonia, positioning it as a potential treatment option for this condition, results from the phase III REPROVE* trial show. Nonetheless, the combination was associated with a higher number of safety events compared with meropenem.