Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

Adherence, persistence to oral anticoagulants in first year of treatment suboptimal

4 days ago

Adherence and persistence to oral anticoagulants (OACs) the first year of treatment appear to be relatively low across drugs, a study has found.

Researchers looked at time trends at individual and system levels, as well as the risk factors for and associations between adherence and persistence, using data from the UK primary care EHR (The Health Information Network 2011–2016).

The analysis included 36,652 individuals with incident atrial fibrillation, cardiovascular comorbidities (median CHA2DS2VASc [Congestive heart failure, Hypertension, Age≥75 years, Diabetes mellitus, Stroke, Vascular disease, Age 65–74 years, Sex category], 3) and polypharmacy (median number of drugs, 6).

Adherence rates at 1 year after treatment initiation were 55.2 percent (95 percent confidence interval [CI], 54.6–55.7) for all OACs, 51.2 percent (95 percent CI, 50.6–51.8) for vitamin K antagonist (VKA), 66.5 percent (95 percent CI, 63.7–69.2) for dabigatran, 63.1 percent (95 percent CI, 61.8–64.4) for rivaroxaban and 64.7 percent (95 percent CI, 63.2–66.1) for apixaban.

One-year persistence rates were 65.9 percent (95 percent CI, 65.4–66.5) for all OACs, 63.4 percent (95 percent CI, 62.8–64.0) for VKA, 61.4 percent (95 percent CI, 58.3–64.2) for dabigatran, 72.3 percent (95 percent CI, 70.9–73.7) for rivaroxaban and 78.7 percent (95 percent CI, 77.1–80.1) for apixaban.

Nonadherence and nonpersistence increased over time at individual and system levels. Increasing comorbidity was associated with a lower likelihood of nonadherence and nonpersistence across all OACs.

Overall, the rate of ‘primary nonadherence’ (stopping after first prescription) was 3.5 percent, ‘nonadherent nonpersistence’ 26.5 percent and ‘persistent adherence’ 40.2 percent. These rates varied across OACs.

The present data may help to better understand the determinants of adherence and persistence, and to design and target interventions to improve adherence and persistence together across drugs, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.