Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
2 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, Yesterday

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Adherence, persistence to oral anticoagulants in first year of treatment suboptimal

08 Nov 2019

Adherence and persistence to oral anticoagulants (OACs) the first year of treatment appear to be relatively low across drugs, a study has found.

Researchers looked at time trends at individual and system levels, as well as the risk factors for and associations between adherence and persistence, using data from the UK primary care EHR (The Health Information Network 2011–2016).

The analysis included 36,652 individuals with incident atrial fibrillation, cardiovascular comorbidities (median CHA2DS2VASc [Congestive heart failure, Hypertension, Age≥75 years, Diabetes mellitus, Stroke, Vascular disease, Age 65–74 years, Sex category], 3) and polypharmacy (median number of drugs, 6).

Adherence rates at 1 year after treatment initiation were 55.2 percent (95 percent confidence interval [CI], 54.6–55.7) for all OACs, 51.2 percent (95 percent CI, 50.6–51.8) for vitamin K antagonist (VKA), 66.5 percent (95 percent CI, 63.7–69.2) for dabigatran, 63.1 percent (95 percent CI, 61.8–64.4) for rivaroxaban and 64.7 percent (95 percent CI, 63.2–66.1) for apixaban.

One-year persistence rates were 65.9 percent (95 percent CI, 65.4–66.5) for all OACs, 63.4 percent (95 percent CI, 62.8–64.0) for VKA, 61.4 percent (95 percent CI, 58.3–64.2) for dabigatran, 72.3 percent (95 percent CI, 70.9–73.7) for rivaroxaban and 78.7 percent (95 percent CI, 77.1–80.1) for apixaban.

Nonadherence and nonpersistence increased over time at individual and system levels. Increasing comorbidity was associated with a lower likelihood of nonadherence and nonpersistence across all OACs.

Overall, the rate of ‘primary nonadherence’ (stopping after first prescription) was 3.5 percent, ‘nonadherent nonpersistence’ 26.5 percent and ‘persistent adherence’ 40.2 percent. These rates varied across OACs.

The present data may help to better understand the determinants of adherence and persistence, and to design and target interventions to improve adherence and persistence together across drugs, according to the researchers.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
2 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, Yesterday

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.