Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
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ADHD, anxiety signal increased risk of bipolar disorder

07 Sep 2018

Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.

Researchers followed a birth cohort of 2,409,236 individuals born in Denmark. A total of 9,250 (mean age at onset 33.49 years) developed bipolar disorder over 37,394,865 person-years follow-up, corresponding to an incidence rate of 2.47 per 10,000 person-years.

The incidence rate of bipolar disorder per 10,000 person-years was 23.86 in individuals with a prior ADHD diagnosis only, 26.05 in those with prior anxiety only, 66.16 in those with prior diagnoses of both conditions, and 2.17 in those without prior ADHD and anxiety.

On Poisson regression analysis, a prior diagnosis of ADHD or anxiety increased the incidence of bipolar disorder up to tenfold (adjusted incidence rate ratio [IRR], 10.00; 95 percent CI, 8.58–11.57 and IRR, 9.61; 9.01–10.24, respectively; p<0.001 for both).

ADHD and anxiety exerted a joint effect, conferring a substantially greater risk when compared with either condition alone. The adjusted IRR for bipolar disorder was 21.15 (15.02–28.78; p<0.001) in the presence of both conditions.

According to researchers, the findings support the hypothesis that predisposition to bipolar disorder overlaps with both internalizing and externalizing psychopathology. As such, pre-emptive interventions may be considered in individuals with both ADHD and anxiety disorders to reduce the risk of bipolar disorder.

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Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.