Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.

ADHD, anxiety signal increased risk of bipolar disorder

07 Sep 2018

Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.

Researchers followed a birth cohort of 2,409,236 individuals born in Denmark. A total of 9,250 (mean age at onset 33.49 years) developed bipolar disorder over 37,394,865 person-years follow-up, corresponding to an incidence rate of 2.47 per 10,000 person-years.

The incidence rate of bipolar disorder per 10,000 person-years was 23.86 in individuals with a prior ADHD diagnosis only, 26.05 in those with prior anxiety only, 66.16 in those with prior diagnoses of both conditions, and 2.17 in those without prior ADHD and anxiety.

On Poisson regression analysis, a prior diagnosis of ADHD or anxiety increased the incidence of bipolar disorder up to tenfold (adjusted incidence rate ratio [IRR], 10.00; 95 percent CI, 8.58–11.57 and IRR, 9.61; 9.01–10.24, respectively; p<0.001 for both).

ADHD and anxiety exerted a joint effect, conferring a substantially greater risk when compared with either condition alone. The adjusted IRR for bipolar disorder was 21.15 (15.02–28.78; p<0.001) in the presence of both conditions.

According to researchers, the findings support the hypothesis that predisposition to bipolar disorder overlaps with both internalizing and externalizing psychopathology. As such, pre-emptive interventions may be considered in individuals with both ADHD and anxiety disorders to reduce the risk of bipolar disorder.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.