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2 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
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Jairia Dela Cruz, Yesterday
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Add-on valganciclovir yields survival gains in glioblastoma

22 Aug 2020

Use of the antiviral drug valganciclovir as an adjunct to standard therapy in patients with newly diagnosed glioblastoma appears to prolong survival, even in the presence of an unmethylated MGMT promoter gene and regardless of when given after surgery, according to the results of an experimental study.

The study included 102 patients (median age, 59 years; 71 percent male) who were given valganciclovir as add-on to standard therapy and 231 controls (median age, 63 years; 62.8 percent male) who did not receive the add-on. Most of the patients received long-term treatment with the antiviral drug (median, 15.6 months), with only 16 patients receiving 6 months of therapy or less.

Valganciclovir treatment was discontinued due to haematological toxicity in six patients, skin rash in two, myocardial ischaemia in one (not related to treatment), infection in three, and diarrhoea in one. No additional toxicity was observed.

Compared with controls, patients who received the antiviral drug had significantly better overall survival (median, 24.1 vs 13.3 months; p<0.0001), higher 2-year survival rate (49.8 percent vs 17.3 percent), and longer time-to-tumour progression (median, 9.9 vs 7.3 months; p=0.0003).

The survival benefits conferred by valganciclovir were observed in patients with radical or partial resection and those with an unmethylated or methylated MGMT promoter gene.

The findings are expected to prompt further investigation into the role of cytomegalovirus in the pathogenesis of glioblastoma.

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Most Read Articles
2 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Jairia Dela Cruz, Yesterday
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.