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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
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Add-on valganciclovir yields survival gains in glioblastoma

22 Aug 2020

Use of the antiviral drug valganciclovir as an adjunct to standard therapy in patients with newly diagnosed glioblastoma appears to prolong survival, even in the presence of an unmethylated MGMT promoter gene and regardless of when given after surgery, according to the results of an experimental study.

The study included 102 patients (median age, 59 years; 71 percent male) who were given valganciclovir as add-on to standard therapy and 231 controls (median age, 63 years; 62.8 percent male) who did not receive the add-on. Most of the patients received long-term treatment with the antiviral drug (median, 15.6 months), with only 16 patients receiving 6 months of therapy or less.

Valganciclovir treatment was discontinued due to haematological toxicity in six patients, skin rash in two, myocardial ischaemia in one (not related to treatment), infection in three, and diarrhoea in one. No additional toxicity was observed.

Compared with controls, patients who received the antiviral drug had significantly better overall survival (median, 24.1 vs 13.3 months; p<0.0001), higher 2-year survival rate (49.8 percent vs 17.3 percent), and longer time-to-tumour progression (median, 9.9 vs 7.3 months; p=0.0003).

The survival benefits conferred by valganciclovir were observed in patients with radical or partial resection and those with an unmethylated or methylated MGMT promoter gene.

The findings are expected to prompt further investigation into the role of cytomegalovirus in the pathogenesis of glioblastoma.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.