Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 20 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Add-on tacrolimus a viable option for RA patients with insufficient abatacept response

25 Nov 2019

Use of tacrolimus (TAC) appears to be safe and effective in the management of rheumatoid arthritis (RA) patients with inadequate response to abatacept, as shown in a recent study.

The analysis included 25 abatacept-treated RA patients (mean age, 67.0 years; disease duration, 16.2 years) who received add-on TAC therapy and were followed for >24 weeks. The mean duration of abatacept treatment at TAC initiation was 1.2 years, with a mean dose of 1.2 mg/d at baseline and 1.6 mg/d at week 24. Many patients had a pulmonary comorbidity (10 patients; 40.0 percent), including six with interstitial pneumonia and four with old pulmonary tuberculosis.

Majority of the patients (84.0 percent) did not use concomitant methotrexate (MTX), the reasons for which included the following: interstitial pneumonia, pulmonary tuberculosis, bacterial pneumonia, sore throat, renal dysfunction, septic shock, physician judgment and patient preference.

There were 20 patients (80 percent) who were treated with abatacept without any concomitant conventional synthetic disease modifying antirheumatic drugs. More than half of the patients were treated with oral glucocorticoids. Mean disease activity as assessed by DAS28‐ESR score was 4.97, corresponding to moderate disease activity.

Mean Disease Activity Score of 28 joints-erythrocyte sedimentation rate decreased substantially, from 4.97 at baseline to 3.35 at week 24. The rate of low disease activity or remission was 40.0 percent, while that of moderate or good response according to the European League Against Rheumatism criteria was 72.0 percent.

Kaplan-Meier analysis showed that the abatacept retention rate was high at 92.0 percent at week 24. Only one patient discontinued TAC therapy due to an adverse event (itching sensation).

The present data indicate that TAC therapy is a viable complementary treatment option in daily clinical practice, researchers said.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 20 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.