Most Read Articles
Tristan Manalac, 04 May 2019
Peppermint oil may be effective for relieving dysphagia and chest pain caused by oesophageal motility disorders, according to a new study.
20 Mar 2019
Adequate tea drinking (<240 ml/day or 19 cup-years) may help lower the risk of gallstones in both men and women, a recent Taiwan study has shown.
Roshini Claire Anthony, 07 May 2019

The trend in liver disease-related mortality in individuals with HIV has changed, with a reduction in the incidence of viral hepatitis-related deaths and an increase in non-alcoholic fatty liver disease (NAFLD)-related deaths, according to a study presented at the International Liver Congress (ILC 2019).

Add-on sublingual nitrate improves diclofenac for preventing post-ECRP pancreatitis

08 May 2019
Type 3c diabetes is caused by injury to the pancreas, and is often misdiagnosed as type 2 diabetes.

Prophylaxis with rectal diclofenac together with sublingual nitrate reduces the incidence of postendoscopic retrograde cholangiopancreatography (post-ECRP) pancreatitis (PEP) more than with diclofenac alone, a recent trial has found.

The study included patients who were scheduled to receive ERCP who were randomized to either the combination group (diclofenac with sublingual nitrate tablet; n=444; median age, 68 years; 64.4 percent male) or diclofenac-alone group (n=442; median age, 68 years; 64.7 percent male). The main study outcome was the incidence of PEP.

A total of 67 patients (7.6 percent) developed PEP over the study duration. This rate was higher in patients who received diclofenac alone (9.5 percent; n=42) than in those who were given the combination intervention (5.6 percent; n=25). The resulting difference in risk was statistically significant (relative risk, 0.59; 95 percent CI, 0.37–0.95; p=0.03).

A similar pattern was observed for moderate or severe PEP. The corresponding incidence rates in the combination and diclofenac-alone groups were 0.9 percent (n=4) and 2.3 percent (n=10). However, the resulting difference in risk failed to reach significance (relative risk, 0.12; 0.13–1.26; p=0.12).

Trends were also largely reflected in the subgroup of high-risk patients. The PEP incidence rate was 8.3 percent (n=24) in the combination treatment group and 13 percent (n=39) in the diclofenac-alone group. The risk difference was only of borderline significance (relative risk, 0.64; 0.39–1.03; p=0.08).

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Most Read Articles
Tristan Manalac, 04 May 2019
Peppermint oil may be effective for relieving dysphagia and chest pain caused by oesophageal motility disorders, according to a new study.
20 Mar 2019
Adequate tea drinking (<240 ml/day or 19 cup-years) may help lower the risk of gallstones in both men and women, a recent Taiwan study has shown.
Roshini Claire Anthony, 07 May 2019

The trend in liver disease-related mortality in individuals with HIV has changed, with a reduction in the incidence of viral hepatitis-related deaths and an increase in non-alcoholic fatty liver disease (NAFLD)-related deaths, according to a study presented at the International Liver Congress (ILC 2019).