Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.

Add-on sublingual nitrate improves diclofenac for preventing post-ECRP pancreatitis

08 May 2019
Type 3c diabetes is caused by injury to the pancreas, and is often misdiagnosed as type 2 diabetes.

Prophylaxis with rectal diclofenac together with sublingual nitrate reduces the incidence of postendoscopic retrograde cholangiopancreatography (post-ECRP) pancreatitis (PEP) more than with diclofenac alone, a recent trial has found.

The study included patients who were scheduled to receive ERCP who were randomized to either the combination group (diclofenac with sublingual nitrate tablet; n=444; median age, 68 years; 64.4 percent male) or diclofenac-alone group (n=442; median age, 68 years; 64.7 percent male). The main study outcome was the incidence of PEP.

A total of 67 patients (7.6 percent) developed PEP over the study duration. This rate was higher in patients who received diclofenac alone (9.5 percent; n=42) than in those who were given the combination intervention (5.6 percent; n=25). The resulting difference in risk was statistically significant (relative risk, 0.59; 95 percent CI, 0.37–0.95; p=0.03).

A similar pattern was observed for moderate or severe PEP. The corresponding incidence rates in the combination and diclofenac-alone groups were 0.9 percent (n=4) and 2.3 percent (n=10). However, the resulting difference in risk failed to reach significance (relative risk, 0.12; 0.13–1.26; p=0.12).

Trends were also largely reflected in the subgroup of high-risk patients. The PEP incidence rate was 8.3 percent (n=24) in the combination treatment group and 13 percent (n=39) in the diclofenac-alone group. The risk difference was only of borderline significance (relative risk, 0.64; 0.39–1.03; p=0.08).

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Most Read Articles
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
31 May 2019
Co-therapy with proton pump inhibitors (PPIs) in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease confers no benefit for upper gastrointestinal events but may reduce bleeding due to gastroduodenal lesions, a study has shown.
07 Aug 2019
Proton pump inhibitor therapy, particularly with pantoprazole, does not reduce upper gastrointestinal bleeding events in patients taking low-dose anticoagulation/aspirin treatment, reports a recent study.
18 Jul 2019
Colonoscopy in patients under propofol sedation may be enhanced with the water exchange (WE) method by significantly improving colon cleanliness and overall adenoma detection rate (ADR), suggests a recent study.