Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Elvira Manzano, Roshini Claire Anthony, 01 Oct 2019

The European Society of Cardiology (ESC) has released five new guidelines at the ESC Congress 2019, recommending an even lower LDL-C* target in patients at very high risk for cardiovascular disease (CVD), and the use of SGLT2** inhibitors and GLP-1*** receptor agonists as first-line treatments in those with diabetes to reduce their CVD risk.

Roshini Claire Anthony, 16 Dec 2016

Five years of extended therapy with the aromatase inhibitor (AI) letrozole did not improve survival in postmenopausal breast cancer patients, according to findings of the NRG Oncology/NSABP B-42 trial presented at the San Antonio Breast Cancer Symposium (SABCS 2016) held in Texas, US. 

Jackey Suen, 21 Dec 2016

Adding everolimus to fulvestrant in second-line treatment of hormone receptor (HR)-positive, HER2-negative advanced breast cancer improves progression-free survival (PFS) by 40 percent, the phase II PrECOG 0102 study has shown. [SABCS 2016, abstract S1-02]

Add-on stiripentol useful for long-term treatment of refractory epilepsies

28 Nov 2019

Use of stiripentol as an adjunctive treatment in patients with different types of refractory epilepsies, including focal onset epilepsy without bilateral tonic‐clonic seizures, has demonstrated long-term efficacy in a prospective observational study.

Researchers followed 132 individuals (age, 5 months to 43 years) consecutively treated with stiripentol as an adjunctive therapy for refractory epilepsies for a median of 14.8 months. Of these patients, 30 had Dravet syndrome (DS),

Stiripentol was administered at a starting dose of 10–15 mg/kg/d, with weekly increments up to a maximum of 50 mg/kg/d based on both age and weight. Epilepsy aetiology was classified as structural, genetic, infectious, immune, metabolic and unknown.

In the cohort, 29 patients (22 percent) received more than two antiepileptic drugs. The most commonly used add-on drugs were benzodiazepines, mainly clobazam. Sixty-six patients (50 percent) achieved response, defined as a reduction in seizure frequency of ≥50 percent), and 13 of them (9.8 percent) were seizure‐free.

The rate of response was higher in the genetic aetiology group (57 percent), particularly in DS (18/30; 60 percent), and in the group of patients with refractory focal onset epilepsy without bilateral tonic‐clonic seizures (5/15; 33 percent).

Median relapse‐free survival rate was 27 months in the 66 responders. The median time to stiripentol failure was 24.6 months in the entire cohort.

More prospectively designed studies are required to confirm the efficacy of stiripentol in focal epilepsy, the researchers said.

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Elvira Manzano, Roshini Claire Anthony, 01 Oct 2019

The European Society of Cardiology (ESC) has released five new guidelines at the ESC Congress 2019, recommending an even lower LDL-C* target in patients at very high risk for cardiovascular disease (CVD), and the use of SGLT2** inhibitors and GLP-1*** receptor agonists as first-line treatments in those with diabetes to reduce their CVD risk.

Roshini Claire Anthony, 16 Dec 2016

Five years of extended therapy with the aromatase inhibitor (AI) letrozole did not improve survival in postmenopausal breast cancer patients, according to findings of the NRG Oncology/NSABP B-42 trial presented at the San Antonio Breast Cancer Symposium (SABCS 2016) held in Texas, US. 

Jackey Suen, 21 Dec 2016

Adding everolimus to fulvestrant in second-line treatment of hormone receptor (HR)-positive, HER2-negative advanced breast cancer improves progression-free survival (PFS) by 40 percent, the phase II PrECOG 0102 study has shown. [SABCS 2016, abstract S1-02]