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Add-on phentermine enhances weight loss in obese teens

11 Jan 2017

Short-term use of the norepinephrine reuptake inhibitor phentermine in addition to standard of care (SOC) lifestyle modification therapy may lead to greater weight loss in adolescents with obesity compared with SOC alone, according to a study.

Researchers examined the medical records of obese adolescents treated in a paediatric weight management clinic to examine the effect of using phentermine as an add-on to SOC lifestyle modification therapy. The population comprised 25 patients (mean age 16.1 years; mean BMI, 41.2 kgm−2) receiving phentermine plus SOC and 274 patients (mean age 14.9 years; mean BMI, 38.1 kgm−2) receiving only SOC.

The patients were evaluated at 1, 3 and 6 months using generalized estimated equations to determine the differences between the two treatment interventions. Age, sex and BMI were included in the analysis as potential confounders. Robust variance standard error estimates were used to calculate confidence intervals and p-values.

Results showed that the percent change in BMI overall was greater in the phentermine group than in the SOC-only group. The respective changes at 1, 3 and 6 months were −1.6 percent (95 percent CI, −2.6 to −0.6; p=0.001), −2.9 percent (−4.5 to −1.4; p<0.001) and −4.1 percent (−7.1 to −1.0; p=0.009).

There were no significant intergroup differences in systolic or diastolic blood pressure. However, heart rate was higher in patients receiving phentermine plus SOC at all time points.

Given the present data and phentermine’s long track record without major safety concerns, the norepinephrine reuptake inhibitor is a viable treatment option for paediatric obesity.

Further investigation should be conducted regarding the efficacy of phentermine as a monotherapy or in combination with other medications in paediatric obesity, researchers said. Future clinical trials should explore potential mechanisms of action and predictors of response, as well as include additional endpoints such as changes in cardiometabolic risk factors, quality of life and noninvasive vascular measurements.

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Most Read Articles
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.
Pearl Toh, 14 Nov 2017
Performing percutaneous coronary intervention (PCI) on culprit lesion only, rather than a multivessel PCI, reduces the 30-day composite risk of death or severe renal failure in patients with acute myocardial infarction (MI) complicated by cardiogenic shock and multivessel disease, according to the CULPRIT-SHOCK* study presented at the TCT 2017 Congress held in Denver, Colorado, US.