Most Read Articles
17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.

20 Feb 2019
A recent study has shown that compounded topical pain creams are only as effective as placebo creams in the treatment of localized chronic pain. Their costs are also higher compared with approved compounds, which should discourage routine use.
Pearl Toh, 24 Jul 2018
SGLT-2* inhibitors and GLP-1** agonists were associated with better survival compared with DPP-4*** inhibitors or control (placebo or no treatment) in patients with type 2 diabetes (T2D) who were inadequately controlled on metformin, according to a large network meta-analysis of 236 randomized trials.

Add-on neoadjuvant chemo to surgery ups survival in advanced pancreatic cancer

Elaine Soliven
08 Mar 2019

Neoadjuvant chemotherapy (NACT) followed by surgery was significantly associated with better disease-free survival (DFS) and overall survival (OS) in patients with LAPC* compared with upfront surgery, according to a study presented at the ASCO Gastrointestinal Cancers Symposium 2019 (ASCO GI 2019).

This study involved patients with LAPC who received NACT + surgery (n=135, median age 60 years) or upfront surgery alone (n=359, median age 61 years). Of these, 51 percent had gemcitabine-based regimens and 49 percent had FOLFIRINOX as NACT. [ASCO GI 2019, abstract 312]

Patients who underwent NACT + surgery had a significantly longer DFS and OS compared with upfront surgery alone (median, 9.0 vs 7.1 months; p=0.005 and 25.4 vs 17.1 months; p=0.001, respectively).

In a multivariate analysis of DFS and OS from surgical resection, patients in the NACT + surgery group also showed a significantly better DFS (adjusted hazard ratio [adjHR], 0.72, 95 percent confidence interval [CI], 0.56–0.93; p=0.01] and OS (adjHR, 0.73, 95 percent CI, 0.56–0.96; p=0.02) than those in the upfront surgery alone group.

Compared with patients in the upfront surgery alone group, those in the NACT + surgery group had a significantly lower incidence of T3–T4 stage tumours (93 percent vs 99 percent; p=0.001) and N1 stage lymph nodes (49 percent vs 71 percent; p<0.01).

Even though hospital admission rates for surgery were not significantly different between the two treatment groups, a significantly lower rate of surgical complication was noted in patients treated with NACT + surgery compared with upfront surgery alone (27 percent vs 38 percent; p=0.03).

“Although NACT has been widely investigated [in previous studies], the magnitude of the clinical benefit and the potential risk of NACT followed by surgery compared with upfront surgery remains unclear for patients with LAPC,” said study lead author Dr Jun Ho Kang from the Department of Oncology at Asan Medical Center, University of Ulsan College of Medicine in Seoul, Korea.

Kang and colleagues highlighted that this “present study revealed that NACT followed by surgery may provide survival benefit compared with upfront surgery in LAPC without causing significant safety issues.”

“[However,] further prospective studies are needed to validate our results,” they added.

 

*LAPC: Locally advanced pancreatic cancer

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Most Read Articles
17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.

20 Feb 2019
A recent study has shown that compounded topical pain creams are only as effective as placebo creams in the treatment of localized chronic pain. Their costs are also higher compared with approved compounds, which should discourage routine use.
Pearl Toh, 24 Jul 2018
SGLT-2* inhibitors and GLP-1** agonists were associated with better survival compared with DPP-4*** inhibitors or control (placebo or no treatment) in patients with type 2 diabetes (T2D) who were inadequately controlled on metformin, according to a large network meta-analysis of 236 randomized trials.