Most Read Articles
Stephen Padilla, 12 Feb 2020
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Add-on humanized antidisialoganglioside mAb improves outcomes in paediatric neuroblastoma

09 Dec 2019

Using a humanized antidisialoganglioside mAb (hu14.18K322A) in combination with induction chemotherapy appears to yield favourable outcomes in children with high-risk neuroblastoma, including induction of an early response, improvement of Curie scores (CSs) and a 2-year event-free survival (EFS), according to the results of a phase II trial.

A total of 42 patients received hu14.18K322A, which was coadministered with six courses of induction chemotherapy and followed with granulocyte–macrophage colony-stimulating factor (GM-CSF) and low-dose interleukin-2 (IL2). A busulfan/melphalan preparative regimen was used during consolidation therapy. An additional course of hu14.18K322A was given with parent-derived natural killer cells, when available, during consolidation. Hu14.18K322A, granulocyte-macrophage colony stimulating factor, IL2 and isotretinoin were then administered.

Results were favourable for the primary outcomes. Partial responses (PR) or better after the first two chemoimmunotherapy courses were documented in 32 patients (76.2 percent, 95 percent confidence interval [CI], 60.6–88.0). Furthermore, most patients achieved 2-year EFS (85.7 percent, 95 percent CI, 70.9–93.3).

The primary tumour volume decreased by a median of 76 percent (range, –100 percent to 5 percent). Thirty-one of 35 patients with stage IV disease who completed induction had CSs of 2. None of the patients experienced progression during induction.

Researchers believe that the current findings, if validated in a larger study, may change the standard of care for children with high-risk neuroblastoma.

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Most Read Articles
Stephen Padilla, 12 Feb 2020
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.