Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
12 Dec 2016

Associate Professor Ng Lee Ching, Director of the Environmental Health Institute (EHI) at the National Environment Agency (NEA), Singapore, speaks about the role of primary care physicians and government agencies in preventing dengue epidemics.

22 Aug 2018
In patients with atrial fibrillation (AF) naïve to oral anticoagulants (OACs), standard-dose nonvitamin K antagonist OACs (NOACs) provides better survival benefits than warfarin, a recent meta-analysis has shown.
Stephen Padilla, 31 Aug 2018
Treatment with rivaroxaban results in less recurrent venous thromboembolism (VTE) in frail patients with VTE, with similar good bleeding outcomes, compared with warfarin, reports a study.

Add-on curcumin nanomicelle beneficial in rheumatoid arthritis treatment

04 Oct 2019

The addition of curcumin nanomicelle to the treatment regimen of patients with rheumatoid arthritis (RA) positively influences several outcomes, although not meaningfully, as shown in a trial.

A total of 65 RA patients were randomized to receive either a curcumin nanomicelle 40 mg (n=30) or placebo (n=35) capsule three times a day for 12 weeks. Researchers measured the Disease Activity Score of 28 joints (DAS‐28) and erythrocyte sedimentation rate (ESR) at baseline and after 12 weeks.

Results showed that DAS‐28, tender joint count (TJC) and swollen joint count (SJC) improved substantially from baseline at the end of treatment in both the curcumin and placebo groups. There were no significant between-group differences seen in the magnitude of change, as well as in baseline values. Nonetheless, the improvements were numerically greater in the active treatment group.

No significant changes were documented in ESR between the two treatment groups.

A major extraction derived from turmeric, curcumin possesses excellent antitumour, antimicrobial and antioxidant properties. However, the substance has poor bioavailability owing to its poor solubility, poor absorption, rapid metabolism and quick systemic elimination, all of which limits its therapeutic effect in vivo. To resolve these limitations, various nanomicelles have been used to construct a protective structure, which works both to prolong its circulation inside the body and to enhance its solubility. [ACS Appl Mater Interfaces 2018;10:23595-23604]

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Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
12 Dec 2016

Associate Professor Ng Lee Ching, Director of the Environmental Health Institute (EHI) at the National Environment Agency (NEA), Singapore, speaks about the role of primary care physicians and government agencies in preventing dengue epidemics.

22 Aug 2018
In patients with atrial fibrillation (AF) naïve to oral anticoagulants (OACs), standard-dose nonvitamin K antagonist OACs (NOACs) provides better survival benefits than warfarin, a recent meta-analysis has shown.
Stephen Padilla, 31 Aug 2018
Treatment with rivaroxaban results in less recurrent venous thromboembolism (VTE) in frail patients with VTE, with similar good bleeding outcomes, compared with warfarin, reports a study.