Most Read Articles
Jairia Dela Cruz, 12 Dec 2019
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
Rachel Soon, 2 days ago

Pharmaceutical industry representatives highlighted lesser-known career opportunities for licensed pharmacists at the recent Pharmaceutical Industries Pharmacists Insights 3.0 (PIPI 3.0) symposium in Petaling Jaya.

Pearl Toh, 13 Oct 2018
An observational study reveals that many hypertensive women stop taking their antihypertensive medications during pregnancy, although it was unclear whether it was appropriate to do so.
Rachel Soon, Yesterday

Lim Jack Shen, assistant general manager of business development at Berjaya Corporation, talks about his experiences with developing MyTigas Alliance, a collaboration of independent community pharmacies for providing group healthcare services.

Add-on curcumin nanomicelle beneficial in rheumatoid arthritis treatment

04 Oct 2019

The addition of curcumin nanomicelle to the treatment regimen of patients with rheumatoid arthritis (RA) positively influences several outcomes, although not meaningfully, as shown in a trial.

A total of 65 RA patients were randomized to receive either a curcumin nanomicelle 40 mg (n=30) or placebo (n=35) capsule three times a day for 12 weeks. Researchers measured the Disease Activity Score of 28 joints (DAS‐28) and erythrocyte sedimentation rate (ESR) at baseline and after 12 weeks.

Results showed that DAS‐28, tender joint count (TJC) and swollen joint count (SJC) improved substantially from baseline at the end of treatment in both the curcumin and placebo groups. There were no significant between-group differences seen in the magnitude of change, as well as in baseline values. Nonetheless, the improvements were numerically greater in the active treatment group.

No significant changes were documented in ESR between the two treatment groups.

A major extraction derived from turmeric, curcumin possesses excellent antitumour, antimicrobial and antioxidant properties. However, the substance has poor bioavailability owing to its poor solubility, poor absorption, rapid metabolism and quick systemic elimination, all of which limits its therapeutic effect in vivo. To resolve these limitations, various nanomicelles have been used to construct a protective structure, which works both to prolong its circulation inside the body and to enhance its solubility. [ACS Appl Mater Interfaces 2018;10:23595-23604]

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Most Read Articles
Jairia Dela Cruz, 12 Dec 2019
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
Rachel Soon, 2 days ago

Pharmaceutical industry representatives highlighted lesser-known career opportunities for licensed pharmacists at the recent Pharmaceutical Industries Pharmacists Insights 3.0 (PIPI 3.0) symposium in Petaling Jaya.

Pearl Toh, 13 Oct 2018
An observational study reveals that many hypertensive women stop taking their antihypertensive medications during pregnancy, although it was unclear whether it was appropriate to do so.
Rachel Soon, Yesterday

Lim Jack Shen, assistant general manager of business development at Berjaya Corporation, talks about his experiences with developing MyTigas Alliance, a collaboration of independent community pharmacies for providing group healthcare services.