Most Read Articles
05 Dec 2017
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
4 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.

Add-on cilostazol potentially alleviates primary negative symptoms of schizophrenia

17 Aug 2017

An 8-week treatment course with cilostazol as an adjunct to risperidone demonstrates a favourable safety and efficacy profile in patients with schizophrenia, improving primary negative symptoms without resulting in serious adverse events requiring medical intervention, a study has shown.

A total of 84 patients with chronic schizophrenia were randomized to receive 8 weeks of treatment with either cilostazol (50 mg twice daily; n=42; mean age 37.4 years; 22.7 percent female) or placebo (n=42; mean age 36.19 years; 22.7 percent female) as an add-on to risperidone. Assessment of the positive and negative syndrome scale (PANSS) was performed at baseline and at weeks 2, 4, 6 and 8. The main outcome measure was the PANSS negative subscale score.

In a general linear model repeated measures, a significant effect for time × treatment interaction was observed on negative subscale and PANSS total scores (p<0.001 and p=0.006, respectively) but not on the PANSS positive and general subscale scores (p=0.37 and p=0.06, respectively).

Compared with those on placebo, patients on cilostazol showed significantly greater improvement in the PANSS total score (mean change from baseline, 17.04 vs 11.42; p=0.01) and negative subscale scores (mean change from baseline, 4.85 vs 2.54; p<0.001) at week 8.

Frequency of adverse events did not significantly differ between the two treatment groups. No serious adverse event was observed.

The present data lend support to the notion that cilostazol can help improve the negative symptoms of schizophrenia, researchers said. However, more studies with larger sample size and longer treatment periods are needed to examine the long‐term safety, efficacy and optimal dosage of the drug.

Primary negative symptoms of schizophrenia are not secondary to extrapyramidal, depressive or positive symptoms, but are instead the core features of schizophrenia. The symptoms—which include deficits in social and emotional functioning, blunted affect and lack of spontaneity—are associated with long‐term functional disability and poor outcome. [Schizophrenia Bulletin 2006;32:214–219; CNS Drugs 2003;17:793–823]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
05 Dec 2017
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
4 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.